SDF1 reduces interneuron leading process branching through dual regulation of actin and microtubules

Normal cerebral cortical function requires a highly ordered balance between projection neurons and interneurons. During development these two neuronal populations migrate from distinct progenitor zones to form the cerebral cortex, with interneurons originating in the more distant ganglionic eminence...

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Veröffentlicht in:	The Journal of neuroscience 2014-04, Vol.34 (14), p.4941-4962
Hauptverfasser:	Lysko, Daniel E, Putt, Mary, Golden, Jeffrey A
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - physiology Animals Cells, Cultured Chemokine CXCL12 - genetics Chemokine CXCL12 - metabolism Chemokine CXCL12 - pharmacology Chlorocebus aethiops Doublecortin Protein Embryo, Mammalian Enzyme Inhibitors - pharmacology Gene Expression Regulation - drug effects Geniculate Bodies - cytology Green Fluorescent Proteins - genetics Green Fluorescent Proteins - metabolism Homeodomain Proteins - genetics Humans Interneurons - drug effects Interneurons - physiology Mice Mice, Inbred C57BL Mice, Transgenic Microtubules - physiology Organ Culture Techniques Signal Transduction - drug effects Signal Transduction - physiology Tubulin Modulators - pharmacology
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