Aberrant functional connectivity in dissociable hippocampal networks is associated with deficits in memory

In the healthy human brain, evidence for dissociable memory networks along the anterior-posterior axis of the hippocampus suggests that this structure may not function as a unitary entity. Failure to consider these functional divisions may explain diverging results among studies of memory adaptation...

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Veröffentlicht in:The Journal of neuroscience 2014-04, Vol.34 (14), p.4920-4928
Hauptverfasser: Voets, Natalie L, Zamboni, Giovanna, Stokes, Mark G, Carpenter, Katherine, Stacey, Richard, Adcock, Jane E
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container_issue 14
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container_title The Journal of neuroscience
container_volume 34
creator Voets, Natalie L
Zamboni, Giovanna
Stokes, Mark G
Carpenter, Katherine
Stacey, Richard
Adcock, Jane E
description In the healthy human brain, evidence for dissociable memory networks along the anterior-posterior axis of the hippocampus suggests that this structure may not function as a unitary entity. Failure to consider these functional divisions may explain diverging results among studies of memory adaptation in disease. Using task-based and resting functional MRI, we show that chronic seizures disrupting the anterior medial temporal lobe (MTL) preserve anterior and posterior hippocampal-cortical dissociations, but alter signaling between these and other key brain regions. During performance of a memory encoding task, we found reduced neural activity in human patients with unilateral temporal lobe epilepsy relative to age-matched healthy controls, but no upregulation of fMRI signal in unaffected hippocampal subregions. Instead, patients showed aberrant resting fMRI connectivity within anterior and posterior hippocampal-cortical networks, which was associated with memory decline, distinguishing memory-intact from memory-impaired patients. Our results highlight a critical role for intact hippocampo-cortical functional communication in memory and provide evidence that chronic injury-induced functional reorganization in the diseased MTL is behavioral inefficient.
doi_str_mv 10.1523/JNEUROSCI.4281-13.2014
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subjects Adolescent
Adult
Brain Mapping
Epilepsy, Temporal Lobe - complications
Female
Hippocampus - blood supply
Hippocampus - physiopathology
Humans
Image Processing, Computer-Assisted
Male
Memory Disorders - etiology
Memory Disorders - pathology
Middle Aged
Nerve Net - blood supply
Nerve Net - physiopathology
Neuropsychological Tests
Oxygen - blood
Rest
Statistics as Topic
Statistics, Nonparametric
Young Adult
title Aberrant functional connectivity in dissociable hippocampal networks is associated with deficits in memory
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