Mutants of Cre recombinase with improved accuracy

Despite rapid advances in genome engineering technologies, inserting genes into precise locations in the human genome remains an outstanding problem. It has been suggested that site-specific recombinases can be adapted towards use as transgene delivery vectors. The specificity of recombinases can be...

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Veröffentlicht in:	Nature communications 2013, Vol.4 (1), p.2509-2509, Article 2509
Hauptverfasser:	Eroshenko, Nikolai, Church, George M.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/208/325/2482 631/61/338 Accuracy Base Sequence Binding sites Cell Line DNA - chemistry DNA - metabolism DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism E coli Escherichia coli - genetics Escherichia coli - metabolism Gene Transfer Techniques Genomes Humanities and Social Sciences Humans Integrases - genetics Integrases - metabolism Kinetics Models, Molecular Molecular Sequence Data multidisciplinary Mutation Protein Multimerization Proteins Recombination, Genetic Science Science (multidisciplinary) Transgenes Viral Proteins - genetics Viral Proteins - metabolism
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