p62 at the Crossroads of Autophagy, Apoptosis, and Cancer

The signaling adaptor p62 is a multidomain protein implicated in the activation of the transcription factor NF-κB. Recent findings link p62 activity to the extrinsic apoptosis pathway, and Mathew et al. (2009) now show that the modulation of p62 by autophagy is a key factor in tumorigenesis. These f...

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Veröffentlicht in:	Cell 2009-06, Vol.137 (6), p.1001-1004
Hauptverfasser:	Moscat, Jorge, Diaz-Meco, Maria T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - metabolism Apoptosis Autophagy Humans Neoplasms - metabolism NF-kappa B - metabolism Sequestosome-1 Protein
Online-Zugang:	Volltext
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