Structural insights into G protein-coupled receptor kinase function

The atomic structure of a protein can greatly advance our understanding of molecular recognition and catalysis, properties of fundamental importance in signal transduction. However, a single structure is incapable of fully describing how a protein functions, particularly when allostery is involved....

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Veröffentlicht in:	Current opinion in cell biology 2014-04, Vol.27, p.25-31
Hauptverfasser:	Homan, Kristoff T, Tesmer, John JG
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding Sites Enzyme Activation G-Protein-Coupled Receptor Kinases - antagonists & inhibitors G-Protein-Coupled Receptor Kinases - chemistry G-Protein-Coupled Receptor Kinases - metabolism Humans Internal Medicine Models, Molecular Phospholipids - metabolism Protein Conformation Receptors, G-Protein-Coupled - metabolism Signal Transduction
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