Metabolic suppression identifies new antibacterial inhibitors under nutrient limitation

Identification of antibacterials and then their mechanism of action using metabolic suppression profiling uncovers inhibitors targeting glycine metabolism, PABA and biotin biosynthesis. Characterizing new drugs and chemical probes of biological systems is hindered by difficulties in identifying the...

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Veröffentlicht in:	Nature chemical biology 2013-12, Vol.9 (12), p.796-804
Hauptverfasser:	Zlitni, Soumaya, Ferruccio, Lauren F, Brown, Eric D
Format:	Artikel
Sprache:	eng
Schlagworte:	49 49/47 49/98 631/1647 631/92/1643 631/92/609 64 82 82/83 Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Bacteria Bacterial physiology Biochemical Engineering Biochemistry Bioorganic Chemistry Biosynthesis Biotin Cell Biology Chemistry Chemistry/Food Science Cloning, Molecular Culture Media - chemistry Dietary restrictions E coli Escherichia coli Escherichia coli K12 - drug effects Escherichia coli K12 - metabolism Escherichia coli Proteins - genetics Escherichia coli Proteins - metabolism Gene Deletion Gene Expression Regulation, Bacterial - drug effects Inhibitors Metabolic syndrome Metabolites Nutrients Probes Recombinant Proteins Transcriptome
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