Controlled release of doxorubicin from pH-responsive microgels

Stimuli-responsive hydrogels have enormous potential in drug delivery applications. They can be used for site-specific drug delivery due to environmental variables in the body such as pH and temperature. In this study, we have developed pH-responsive microgels for the delivery of doxorubicin (DOX) i...

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Veröffentlicht in:	Acta biomaterialia 2013-03, Vol.9 (3), p.5438-5446
Hauptverfasser:	Dadsetan, Mahrokh, Taylor, K. Efua, Yong, Chun, Bajzer, Željko, Lu, Lichun, Yaszemski, Michael J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adsorption anticarcinogenic activity Cell Death - drug effects Chemistry, Pharmaceutical Chordoma composite polymers Delayed-Action Preparations Dose-Response Relationship, Drug Doxorubicin Doxorubicin - chemistry Doxorubicin - pharmacology drug delivery systems environmental factors Freeze Drying Fumarates - chemistry Gels - chemistry Humans hydrocolloids Hydrogen-Ion Concentration ion exchange ionic strength mathematical models Methacrylates - chemistry Microgels Microscopy, Confocal Microscopy, Electron, Scanning Microspheres Models, Chemical Oligo(polyethylene glycol) fumarate pH-responsive polyethylene glycol Polyethylene Glycols - chemistry sodium Solutions temperature Time Factors toxicity
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