Redesigning the procaspase‐8 dimer interface for improved dimerization

Caspase‐8 is a cysteine directed aspartate‐specific protease that is activated at the cytosolic face of the cell membrane upon receptor ligation. A key step in the activation of caspase‐8 depends on adaptor‐induced dimerization of procaspase‐8 monomers. Dimerization is followed by limited autoproteo...

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Veröffentlicht in:	Protein science 2014-04, Vol.23 (4), p.442-453
Hauptverfasser:	Ma, Chunxiao, MacKenzie, Sarah H., Clay Clark, A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Antigens Apoptosis Binding Sites Biocatalysis Caspase Caspase 8 - chemistry Caspase 8 - genetics Caspase 8 - metabolism Catalysis Cell membranes Cells, Cultured Crystal structure Dimerization Dimers Domains Enzymatic activity Enzyme Activation HEK293 Cells Humans Kinetics Models, Molecular Monomers Mutants Mutation Mutation - genetics Proenzymes Protein Engineering Protein Multimerization - genetics Transfection
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