Notch1 and Notch2 expression in osteoblast precursors regulates femoral microarchitecture

Abstract Notch receptors regulate cell differentiation and function. Notch1 and Notch2 inactivation in osteoblasts and osteocytes increases cancellous bone volume, but the function of Notch signaling in osteoblast precursors is unknown. To inactivate Notch signaling in immature osteoblastic cells, m...

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Veröffentlicht in:	Bone (New York, N.Y.) N.Y.), 2014-05, Vol.62, p.22-28
Hauptverfasser:	Zanotti, Stefano, Canalis, Ernesto
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Body Weight Cortical bone Female Femur - anatomy & histology Femur - diagnostic imaging Femur - metabolism Fundamental and applied biological sciences. Psychology Gene Silencing Male Mice, Inbred C57BL Notch1 Notch2 Organ Size Orthopedics Osteoblasts Osteoblasts - metabolism Porosity Receptors, Notch - metabolism Vertebrates: anatomy and physiology, studies on body, several organs or systems X-Ray Microtomography
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