Structure-function relationships of ErbB RTKs in the plasma membrane of living cells
We review the states of the ErbB family of receptor tyrosine kinases (RTKs), primarily the EGF receptor (EGFR, ErbB1, HER1) and the orphan receptor ErbB2 as they exist in living mammalian cells, focusing on four main aspects: (1) aggregation state and distribution in the plasma membrane; (2) conform...
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| Veröffentlicht in: | Cold Spring Harbor perspectives in biology 2014-04, Vol.6 (4), p.a008961-a008961 |
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| container_issue | 4 |
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| container_title | Cold Spring Harbor perspectives in biology |
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| creator | Arndt-Jovin, Donna J Botelho, Michelle G Jovin, Thomas M |
| description | We review the states of the ErbB family of receptor tyrosine kinases (RTKs), primarily the EGF receptor (EGFR, ErbB1, HER1) and the orphan receptor ErbB2 as they exist in living mammalian cells, focusing on four main aspects: (1) aggregation state and distribution in the plasma membrane; (2) conformational features of the receptors situated in the plasma membrane, compared to the crystallographic structures of the isolated extracellular domains; (3) coupling of receptor disposition on filopodia with the transduction of signaling ligand gradients; and (4) ligand-independent receptor activation by application of a magnetic field. |
| doi_str_mv | 10.1101/cshperspect.a008961 |
| format | Article |
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| identifier | ISSN: 1943-0264 |
| ispartof | Cold Spring Harbor perspectives in biology, 2014-04, Vol.6 (4), p.a008961-a008961 |
| issn | 1943-0264 1943-0264 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Animals Cell Membrane - metabolism Crystallography, X-Ray Mammals - metabolism Oncogene Proteins v-erbB - chemistry Oncogene Proteins v-erbB - metabolism Oncogene Proteins v-erbB - physiology PERSPECTIVES Protein Aggregates Pseudopodia - metabolism Signal Transduction |
| title | Structure-function relationships of ErbB RTKs in the plasma membrane of living cells |
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