The Next-Generation Sequencing Revolution and Its Impact on Genomics
Genomics is a relatively new scientific discipline, having DNA sequencing as its core technology. As technology has improved the cost and scale of genome characterization over sequencing’s 40-year history, the scope of inquiry has commensurately broadened. Massively parallel sequencing has proven re...
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| Veröffentlicht in: | Cell 2013-09, Vol.155 (1), p.27-38 |
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| container_title | Cell |
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| creator | Koboldt, Daniel C. Steinberg, Karyn Meltz Larson, David E. Wilson, Richard K. Mardis, Elaine R. |
| description | Genomics is a relatively new scientific discipline, having DNA sequencing as its core technology. As technology has improved the cost and scale of genome characterization over sequencing’s 40-year history, the scope of inquiry has commensurately broadened. Massively parallel sequencing has proven revolutionary, shifting the paradigm of genomics to address biological questions at a genome-wide scale. Sequencing now empowers clinical diagnostics and other aspects of medical care, including disease risk, therapeutic identification, and prenatal testing. This Review explores the current state of genomics in the massively parallel sequencing era. |
| doi_str_mv | 10.1016/j.cell.2013.09.006 |
| format | Article |
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| source | MEDLINE; Cell Press Free Archives; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Animals diagnostic techniques Disease - genetics Genetic Variation genome Genomics high-throughput nucleotide sequencing High-Throughput Nucleotide Sequencing - history High-Throughput Nucleotide Sequencing - methods History, 20th Century History, 21st Century Humans Mutation risk Sequence Analysis, DNA - history Sequence Analysis, DNA - methods |
| title | The Next-Generation Sequencing Revolution and Its Impact on Genomics |
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