A potent and Kv1.3-selective analogue of the scorpion toxin HsTX1 as a potential therapeutic for autoimmune diseases

HsTX1 toxin, from the scorpion Heterometrus spinnifer , is a 34-residue, C-terminally amidated peptide cross-linked by four disulfide bridges. Here we describe new HsTX1 analogues with an Ala, Phe, Val or Abu substitution at position 14. Complexes of HsTX1 with the voltage-gated potassium channels K...

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Veröffentlicht in:	Scientific reports 2014-03, Vol.4 (1), p.4509, Article 4509
Hauptverfasser:	Rashid, M. Harunur, Huq, Redwan, Tanner, Mark R., Chhabra, Sandeep, Khoo, Keith K., Estrada, Rosendo, Dhawan, Vikas, Chauhan, Satendra, Pennington, Michael W., Beeton, Christine, Kuyucak, Serdar, Norton, Raymond S.
Format:	Artikel
Sprache:	eng
Schlagworte:	119/118 631/45/611 692/308/153 82/6 9/74 Amino Acid Sequence Animals Autoimmune Diseases - drug therapy Autoimmune Diseases - immunology Autoimmune Diseases - metabolism Cell Line Humanities and Social Sciences Inhibitory Concentration 50 Kv1.1 Potassium Channel - antagonists & inhibitors Kv1.1 Potassium Channel - chemistry Kv1.1 Potassium Channel - metabolism Kv1.3 Potassium Channel - antagonists & inhibitors Kv1.3 Potassium Channel - chemistry Kv1.3 Potassium Channel - metabolism Lymphocyte Activation Mice Models, Molecular Molecular Sequence Data multidisciplinary Peptide Fragments - chemistry Potassium Channel Blockers - chemistry Potassium Channel Blockers - pharmacology Protein Binding Protein Conformation Protein Stability Science Scorpion Venoms - chemistry Scorpion Venoms - pharmacology
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