Whole exome sequencing identifies variation in CYB5A and RNF10 associated with adiposity and type 2 diabetes

Objective Few coding variants in genes associated with type 2 diabetes (T2D) have been identified, and the underlying physiologic mechanisms whereby susceptibility genes influence T2D risk are often unknown. The objective of this study was to identify coding variation that increases risk for T2D via...

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Veröffentlicht in:	Obesity (Silver Spring, Md.) Md.), 2014-04, Vol.22 (4), p.984-988
Hauptverfasser:	Huang, Ke, Nair, Anup K., Muller, Yunhua Li, Piaggi, Paolo, Bian, Li, Rosario, Melissa, Knowler, William C., Kobes, Sayuko, Hanson, Robert L., Bogardus, Clifton, Baier, Leslie J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adiposity - ethnology Adiposity - genetics Adolescent Adult Alleles Blood Glucose - metabolism Body Mass Index Carrier Proteins - genetics Child Child, Preschool Cytochromes b5 - genetics Diabetes Mellitus, Type 2 - epidemiology Diabetes Mellitus, Type 2 - ethnology Diabetes Mellitus, Type 2 - genetics Exome - genetics Female Genetic Predisposition to Disease - ethnology Genetic Predisposition to Disease - genetics Genotype Humans Indians, North American - ethnology Indians, North American - genetics Insulin - blood Male Middle Aged Polymorphism, Single Nucleotide Risk Factors Sequence Analysis, DNA Young Adult
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