Herp coordinates compartmentalization and recruitment of HRD1 and misfolded proteins for ERAD

A functional unfolded protein response (UPR) is essential for endoplasmic reticulum (ER)-associated degradation (ERAD) of misfolded secretory proteins, reflecting the fact that some level of UPR activation must exist under normal physiological conditions. A coordinator of the UPR and ERAD processes...

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Veröffentlicht in:	Molecular biology of the cell 2014-04, Vol.25 (7), p.1050-1060
Hauptverfasser:	Leitman, Julia, Shenkman, Marina, Gofman, Yana, Shtern, Navit Ogen, Ben-Tal, Nir, Hendershot, Linda M, Lederkremer, Gerardo Z
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Compartmentation Cell Line Cell Membrane - metabolism DNA Repair Enzymes DNA-Binding Proteins Endoplasmic Reticulum - metabolism Endoplasmic Reticulum-Associated Degradation Eukaryotic Initiation Factor-2 - metabolism Gene Knockdown Techniques Glycosylation Humans Lectins - metabolism Membrane Proteins - metabolism Mice Models, Biological Mutant Proteins - metabolism Phosphorylation Protein Folding Protein Transport Proteolysis Substrate Specificity Transcription Factor CHOP - metabolism Ubiquitin-Protein Ligases - metabolism Unfolded Protein Response
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