Maternal PTSD associates with greater glucocorticoid sensitivity in offspring of Holocaust survivors
Summary Intergenerational effects of trauma have been observed clinically in a wide range of populations, and parental PTSD has been associated with an increased risk for psychopathology in offspring. In studies of Holocaust survivor offspring, parental PTSD, and particularly maternal PTSD, has been...
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| Veröffentlicht in: | Psychoneuroendocrinology 2014-02, Vol.40, p.213-220 |
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| creator | Lehrner, Amy Bierer, Linda M Passarelli, Vincent Pratchett, Laura C Flory, Janine D Bader, Heather N Harris, Iris R Bedi, Aarti Daskalakis, Nikolaos P Makotkine, Iouri Yehuda, Rachel |
| description | Summary Intergenerational effects of trauma have been observed clinically in a wide range of populations, and parental PTSD has been associated with an increased risk for psychopathology in offspring. In studies of Holocaust survivor offspring, parental PTSD, and particularly maternal PTSD, has been associated with increased risk for PTSD, low basal urinary cortisol excretion and enhanced cortisol suppression in response to dexamethasone. Such findings implicate maternally derived glucocorticoid programming in the intergenerational transmission of trauma-related consequences, potentially resulting from in utero influences or early life experiences. This study investigated the relative influence of Holocaust exposure and PTSD in mothers and fathers on glucocorticoid sensitivity in offspring. Eighty Holocaust offspring and 15 offspring of non-exposed Jewish parents completed evaluations and provided blood and urine samples. Glucocorticoid sensitivity was evaluated using the lysozyme suppression test (LST), an in vitro measure of glucocorticoid receptor sensitivity in a peripheral tissue, the dexamethasone suppression test (DST), and 24-h urinary cortisol excretion. Maternal PTSD was associated with greater glucocorticoid sensitivity in offspring across all three measures of glucocorticoid function. An interaction of maternal and paternal PTSD on the DST and 24-h urinary cortisol showed an effect of decreased glucocorticoid sensitivity in offspring with paternal, but not maternal, PTSD. Although indirect, these findings are consistent with the hypothesis that epigenetic programming may be involved in the intergenerational transmission of trauma-related effects on glucocorticoid regulation. |
| doi_str_mv | 10.1016/j.psyneuen.2013.11.019 |
| format | Article |
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In studies of Holocaust survivor offspring, parental PTSD, and particularly maternal PTSD, has been associated with increased risk for PTSD, low basal urinary cortisol excretion and enhanced cortisol suppression in response to dexamethasone. Such findings implicate maternally derived glucocorticoid programming in the intergenerational transmission of trauma-related consequences, potentially resulting from in utero influences or early life experiences. This study investigated the relative influence of Holocaust exposure and PTSD in mothers and fathers on glucocorticoid sensitivity in offspring. Eighty Holocaust offspring and 15 offspring of non-exposed Jewish parents completed evaluations and provided blood and urine samples. Glucocorticoid sensitivity was evaluated using the lysozyme suppression test (LST), an in vitro measure of glucocorticoid receptor sensitivity in a peripheral tissue, the dexamethasone suppression test (DST), and 24-h urinary cortisol excretion. Maternal PTSD was associated with greater glucocorticoid sensitivity in offspring across all three measures of glucocorticoid function. An interaction of maternal and paternal PTSD on the DST and 24-h urinary cortisol showed an effect of decreased glucocorticoid sensitivity in offspring with paternal, but not maternal, PTSD. Although indirect, these findings are consistent with the hypothesis that epigenetic programming may be involved in the intergenerational transmission of trauma-related effects on glucocorticoid regulation.</description><identifier>ISSN: 0306-4530</identifier><identifier>EISSN: 1873-3360</identifier><identifier>DOI: 10.1016/j.psyneuen.2013.11.019</identifier><identifier>PMID: 24485493</identifier><identifier>CODEN: PSYCDE</identifier><language>eng</language><publisher>Kidlington: Elsevier Ltd</publisher><subject>Adult ; Adult and adolescent clinical studies ; Aged ; Anxiety Disorders - blood ; Anxiety Disorders - epidemiology ; Anxiety Disorders - etiology ; Anxiety Disorders - urine ; Anxiety disorders. Neuroses ; Behavioral psychophysiology ; Biological and medical sciences ; Case-Control Studies ; Child of Impaired Parents ; Cortisol ; Depressive Disorder - blood ; Depressive Disorder - epidemiology ; Depressive Disorder - etiology ; Depressive Disorder - urine ; Dexamethasone suppression test ; Endocrinology & Metabolism ; Fathers - psychology ; Fathers - statistics & numerical data ; Female ; Fundamental and applied biological sciences. Psychology ; Glucocorticoid receptor ; Glucocorticoids - metabolism ; Holocaust ; Holocaust - psychology ; Hormones and behavior ; Humans ; Hydrocortisone - blood ; Hydrocortisone - urine ; Intergenerational ; Male ; Medical sciences ; Middle Aged ; Mothers - psychology ; Mothers - statistics & numerical data ; Post-traumatic stress disorder ; Pregnancy ; Prenatal Exposure Delayed Effects - epidemiology ; Prenatal Exposure Delayed Effects - metabolism ; Prenatal Exposure Delayed Effects - psychology ; Psychiatry ; Psychology. Psychoanalysis. Psychiatry ; Psychology. Psychophysiology ; Psychopathology. Psychiatry ; PTSD ; Risk factor ; Stress Disorders, Post-Traumatic ; Survivors - psychology ; Survivors - statistics & numerical data ; Trauma ; Young Adult</subject><ispartof>Psychoneuroendocrinology, 2014-02, Vol.40, p.213-220</ispartof><rights>2013</rights><rights>2015 INIST-CNRS</rights><rights>Published by Elsevier Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c675t-34959c14538cb918301ead91d8aea34235be96c570f258d68d5bf7ebe4ba91fa3</citedby><cites>FETCH-LOGICAL-c675t-34959c14538cb918301ead91d8aea34235be96c570f258d68d5bf7ebe4ba91fa3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.psyneuen.2013.11.019$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,778,782,883,3539,27907,27908,45978</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28214416$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24485493$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lehrner, Amy</creatorcontrib><creatorcontrib>Bierer, Linda M</creatorcontrib><creatorcontrib>Passarelli, Vincent</creatorcontrib><creatorcontrib>Pratchett, Laura C</creatorcontrib><creatorcontrib>Flory, Janine D</creatorcontrib><creatorcontrib>Bader, Heather N</creatorcontrib><creatorcontrib>Harris, Iris R</creatorcontrib><creatorcontrib>Bedi, Aarti</creatorcontrib><creatorcontrib>Daskalakis, Nikolaos P</creatorcontrib><creatorcontrib>Makotkine, Iouri</creatorcontrib><creatorcontrib>Yehuda, Rachel</creatorcontrib><title>Maternal PTSD associates with greater glucocorticoid sensitivity in offspring of Holocaust survivors</title><title>Psychoneuroendocrinology</title><addtitle>Psychoneuroendocrinology</addtitle><description>Summary Intergenerational effects of trauma have been observed clinically in a wide range of populations, and parental PTSD has been associated with an increased risk for psychopathology in offspring. In studies of Holocaust survivor offspring, parental PTSD, and particularly maternal PTSD, has been associated with increased risk for PTSD, low basal urinary cortisol excretion and enhanced cortisol suppression in response to dexamethasone. Such findings implicate maternally derived glucocorticoid programming in the intergenerational transmission of trauma-related consequences, potentially resulting from in utero influences or early life experiences. This study investigated the relative influence of Holocaust exposure and PTSD in mothers and fathers on glucocorticoid sensitivity in offspring. Eighty Holocaust offspring and 15 offspring of non-exposed Jewish parents completed evaluations and provided blood and urine samples. Glucocorticoid sensitivity was evaluated using the lysozyme suppression test (LST), an in vitro measure of glucocorticoid receptor sensitivity in a peripheral tissue, the dexamethasone suppression test (DST), and 24-h urinary cortisol excretion. Maternal PTSD was associated with greater glucocorticoid sensitivity in offspring across all three measures of glucocorticoid function. An interaction of maternal and paternal PTSD on the DST and 24-h urinary cortisol showed an effect of decreased glucocorticoid sensitivity in offspring with paternal, but not maternal, PTSD. Although indirect, these findings are consistent with the hypothesis that epigenetic programming may be involved in the intergenerational transmission of trauma-related effects on glucocorticoid regulation.</description><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Aged</subject><subject>Anxiety Disorders - blood</subject><subject>Anxiety Disorders - epidemiology</subject><subject>Anxiety Disorders - etiology</subject><subject>Anxiety Disorders - urine</subject><subject>Anxiety disorders. Neuroses</subject><subject>Behavioral psychophysiology</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>Child of Impaired Parents</subject><subject>Cortisol</subject><subject>Depressive Disorder - blood</subject><subject>Depressive Disorder - epidemiology</subject><subject>Depressive Disorder - etiology</subject><subject>Depressive Disorder - urine</subject><subject>Dexamethasone suppression test</subject><subject>Endocrinology & Metabolism</subject><subject>Fathers - psychology</subject><subject>Fathers - statistics & numerical data</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Glucocorticoid receptor</subject><subject>Glucocorticoids - metabolism</subject><subject>Holocaust</subject><subject>Holocaust - psychology</subject><subject>Hormones and behavior</subject><subject>Humans</subject><subject>Hydrocortisone - blood</subject><subject>Hydrocortisone - urine</subject><subject>Intergenerational</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Mothers - psychology</subject><subject>Mothers - statistics & numerical data</subject><subject>Post-traumatic stress disorder</subject><subject>Pregnancy</subject><subject>Prenatal Exposure Delayed Effects - epidemiology</subject><subject>Prenatal Exposure Delayed Effects - metabolism</subject><subject>Prenatal Exposure Delayed Effects - psychology</subject><subject>Psychiatry</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Psychopathology. Psychiatry</subject><subject>PTSD</subject><subject>Risk factor</subject><subject>Stress Disorders, Post-Traumatic</subject><subject>Survivors - psychology</subject><subject>Survivors - statistics & numerical data</subject><subject>Trauma</subject><subject>Young Adult</subject><issn>0306-4530</issn><issn>1873-3360</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUk1vEzEQtRCIhsBfqPaCxCXBXn-s91KBWkqRikBqOVte72zqsLGDZzco_75eJS0fl55sed68ec9vCDlldMkoU-_Xyy3uA4wQliVlfMnYkrL6GZkxXfEF54o-JzPKqVoIyekJeYW4ppQqrcqX5KQUQktR8xlpv9oBUrB98f325qKwiNH5_ITFbz_cFasEU71Y9aOLLqbBu-jbAiGgH_zOD_vChyJ2HW6TD6t8K65iH50dcShwTDu_iwlfkxed7RHeHM85-XH56fb8anH97fOX84_XC6cqOSy4qGXtWBasXVMzzSkD29as1RYsFyWXDdTKyYp2pdSt0q1sugoaEI2tWWf5nJwdeLdjs4HWQRiS7U2WtrFpb6L15t9K8HdmFXeG16rSee6cvDsSpPhrBBzMxqODvrcB4oiGSaYqxYXUT0NFLbIBySdWdYC6FBETdI-KGDVTmmZtHtI0U5qGMZPTzI2nf_t5bHuILwPeHgEWne27ZIPz-AenSyYEUxn34YCD_Ps7D8mg8xActD6BG0wb_dNazv6jcL0PPk_9CXvAdRynLcq-DZaGmptp96bVY5xSwaXi9yAj2Vc</recordid><startdate>20140201</startdate><enddate>20140201</enddate><creator>Lehrner, Amy</creator><creator>Bierer, Linda M</creator><creator>Passarelli, Vincent</creator><creator>Pratchett, Laura C</creator><creator>Flory, Janine D</creator><creator>Bader, Heather N</creator><creator>Harris, Iris R</creator><creator>Bedi, Aarti</creator><creator>Daskalakis, Nikolaos P</creator><creator>Makotkine, Iouri</creator><creator>Yehuda, Rachel</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope><scope>5PM</scope></search><sort><creationdate>20140201</creationdate><title>Maternal PTSD associates with greater glucocorticoid sensitivity in offspring of Holocaust survivors</title><author>Lehrner, Amy ; Bierer, Linda M ; Passarelli, Vincent ; Pratchett, Laura C ; Flory, Janine D ; Bader, Heather N ; Harris, Iris R ; Bedi, Aarti ; Daskalakis, Nikolaos P ; Makotkine, Iouri ; Yehuda, Rachel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c675t-34959c14538cb918301ead91d8aea34235be96c570f258d68d5bf7ebe4ba91fa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>Aged</topic><topic>Anxiety Disorders - blood</topic><topic>Anxiety Disorders - epidemiology</topic><topic>Anxiety Disorders - etiology</topic><topic>Anxiety Disorders - urine</topic><topic>Anxiety disorders. Neuroses</topic><topic>Behavioral psychophysiology</topic><topic>Biological and medical sciences</topic><topic>Case-Control Studies</topic><topic>Child of Impaired Parents</topic><topic>Cortisol</topic><topic>Depressive Disorder - blood</topic><topic>Depressive Disorder - epidemiology</topic><topic>Depressive Disorder - etiology</topic><topic>Depressive Disorder - urine</topic><topic>Dexamethasone suppression test</topic><topic>Endocrinology & Metabolism</topic><topic>Fathers - psychology</topic><topic>Fathers - statistics & numerical data</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Glucocorticoid receptor</topic><topic>Glucocorticoids - metabolism</topic><topic>Holocaust</topic><topic>Holocaust - psychology</topic><topic>Hormones and behavior</topic><topic>Humans</topic><topic>Hydrocortisone - blood</topic><topic>Hydrocortisone - urine</topic><topic>Intergenerational</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Mothers - psychology</topic><topic>Mothers - statistics & numerical data</topic><topic>Post-traumatic stress disorder</topic><topic>Pregnancy</topic><topic>Prenatal Exposure Delayed Effects - epidemiology</topic><topic>Prenatal Exposure Delayed Effects - metabolism</topic><topic>Prenatal Exposure Delayed Effects - psychology</topic><topic>Psychiatry</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. Psychophysiology</topic><topic>Psychopathology. 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In studies of Holocaust survivor offspring, parental PTSD, and particularly maternal PTSD, has been associated with increased risk for PTSD, low basal urinary cortisol excretion and enhanced cortisol suppression in response to dexamethasone. Such findings implicate maternally derived glucocorticoid programming in the intergenerational transmission of trauma-related consequences, potentially resulting from in utero influences or early life experiences. This study investigated the relative influence of Holocaust exposure and PTSD in mothers and fathers on glucocorticoid sensitivity in offspring. Eighty Holocaust offspring and 15 offspring of non-exposed Jewish parents completed evaluations and provided blood and urine samples. Glucocorticoid sensitivity was evaluated using the lysozyme suppression test (LST), an in vitro measure of glucocorticoid receptor sensitivity in a peripheral tissue, the dexamethasone suppression test (DST), and 24-h urinary cortisol excretion. Maternal PTSD was associated with greater glucocorticoid sensitivity in offspring across all three measures of glucocorticoid function. An interaction of maternal and paternal PTSD on the DST and 24-h urinary cortisol showed an effect of decreased glucocorticoid sensitivity in offspring with paternal, but not maternal, PTSD. Although indirect, these findings are consistent with the hypothesis that epigenetic programming may be involved in the intergenerational transmission of trauma-related effects on glucocorticoid regulation.</abstract><cop>Kidlington</cop><pub>Elsevier Ltd</pub><pmid>24485493</pmid><doi>10.1016/j.psyneuen.2013.11.019</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Adult and adolescent clinical studies Aged Anxiety Disorders - blood Anxiety Disorders - epidemiology Anxiety Disorders - etiology Anxiety Disorders - urine Anxiety disorders. Neuroses Behavioral psychophysiology Biological and medical sciences Case-Control Studies Child of Impaired Parents Cortisol Depressive Disorder - blood Depressive Disorder - epidemiology Depressive Disorder - etiology Depressive Disorder - urine Dexamethasone suppression test Endocrinology & Metabolism Fathers - psychology Fathers - statistics & numerical data Female Fundamental and applied biological sciences. Psychology Glucocorticoid receptor Glucocorticoids - metabolism Holocaust Holocaust - psychology Hormones and behavior Humans Hydrocortisone - blood Hydrocortisone - urine Intergenerational Male Medical sciences Middle Aged Mothers - psychology Mothers - statistics & numerical data Post-traumatic stress disorder Pregnancy Prenatal Exposure Delayed Effects - epidemiology Prenatal Exposure Delayed Effects - metabolism Prenatal Exposure Delayed Effects - psychology Psychiatry Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Psychopathology. Psychiatry PTSD Risk factor Stress Disorders, Post-Traumatic Survivors - psychology Survivors - statistics & numerical data Trauma Young Adult |
| title | Maternal PTSD associates with greater glucocorticoid sensitivity in offspring of Holocaust survivors |
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