Design of vaccine adjuvants incorporating TNF superfamily ligands and TNF superfamily molecular mimics
TNF superfamily ligands play a critical role in the regulation of adaptive immune responses, including the costimulation of dendritic cells, T cells, and B cells. This costimulation could potentially be exploited for the development of prophylactic vaccines and immunotherapy. Despite this, there hav...
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| Veröffentlicht in: | Immunologic research 2013-12, Vol.57 (1-3), p.303-310 |
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| creator | Gupta, Sachin Termini, James M. Kanagavelu, Saravana Stone, Geoffrey W. |
| description | TNF superfamily ligands play a critical role in the regulation of adaptive immune responses, including the costimulation of dendritic cells, T cells, and B cells. This costimulation could potentially be exploited for the development of prophylactic vaccines and immunotherapy. Despite this, there have been only a limited number of reports on the use of this family of molecules as gene-based adjuvants to enhance DNA and/or viral vector vaccines. In addition, the molecule latent membrane protein 1 (LMP1), a viral mimic of the TNF superfamily receptor CD40, provides an alternative approach for the design of novel molecular adjuvants. Here, we discuss advances in the development of recombinant TNF superfamily ligands as adjuvants for HIV vaccines and as cancer immunotherapy, including the use of LMP1 and LMP1-CD40 chimeric fusion proteins to mimic constitutive CD40 signaling. |
| doi_str_mv | 10.1007/s12026-013-8443-6 |
| format | Article |
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This costimulation could potentially be exploited for the development of prophylactic vaccines and immunotherapy. Despite this, there have been only a limited number of reports on the use of this family of molecules as gene-based adjuvants to enhance DNA and/or viral vector vaccines. In addition, the molecule latent membrane protein 1 (LMP1), a viral mimic of the TNF superfamily receptor CD40, provides an alternative approach for the design of novel molecular adjuvants. Here, we discuss advances in the development of recombinant TNF superfamily ligands as adjuvants for HIV vaccines and as cancer immunotherapy, including the use of LMP1 and LMP1-CD40 chimeric fusion proteins to mimic constitutive CD40 signaling.</description><identifier>ISSN: 0257-277X</identifier><identifier>EISSN: 1559-0755</identifier><identifier>DOI: 10.1007/s12026-013-8443-6</identifier><identifier>PMID: 24198065</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Adjuvants, Immunologic - chemistry ; Allergology ; Animals ; Biomedical and Life Sciences ; Biomedicine ; Cancer Vaccines - chemistry ; Cancer Vaccines - immunology ; CD40 Antigens - immunology ; CD40 Ligand - chemistry ; CD40 Ligand - metabolism ; Cells ; Genetic Vectors - genetics ; Genetic Vectors - immunology ; Human immunodeficiency virus ; Humans ; Immune system ; Immunology ; Immunology & Microbiology in Miami ; Immunotherapy ; Internal Medicine ; Lentivirus - genetics ; Lentivirus - immunology ; Ligands ; Macaca mulatta ; Medicine/Public Health ; Molecular biology ; Molecular Mimicry - immunology ; Neoplasms - immunology ; Neoplasms - therapy ; Protein Multimerization ; TNF-Related Apoptosis-Inducing Ligand - chemistry ; Toll-Like Receptors - agonists ; Tumor Necrosis Factors - chemistry ; Vaccines ; Vaccines - chemistry ; Vaccines - immunology ; Vaccines, Synthetic - chemistry ; Vaccines, Synthetic - immunology ; Viral Matrix Proteins - immunology</subject><ispartof>Immunologic research, 2013-12, Vol.57 (1-3), p.303-310</ispartof><rights>Springer Science+Business Media New York 2013</rights><rights>Springer Science+Business Media New York 2013 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c503t-50fd77fd5ca5591458c3f33405eeadb8dd7e0da58cfef7f03163f158505c9d703</citedby><cites>FETCH-LOGICAL-c503t-50fd77fd5ca5591458c3f33405eeadb8dd7e0da58cfef7f03163f158505c9d703</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12026-013-8443-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12026-013-8443-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,780,784,885,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24198065$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gupta, Sachin</creatorcontrib><creatorcontrib>Termini, James M.</creatorcontrib><creatorcontrib>Kanagavelu, Saravana</creatorcontrib><creatorcontrib>Stone, Geoffrey W.</creatorcontrib><title>Design of vaccine adjuvants incorporating TNF superfamily ligands and TNF superfamily molecular mimics</title><title>Immunologic research</title><addtitle>Immunol Res</addtitle><addtitle>Immunol Res</addtitle><description>TNF superfamily ligands play a critical role in the regulation of adaptive immune responses, including the costimulation of dendritic cells, T cells, and B cells. This costimulation could potentially be exploited for the development of prophylactic vaccines and immunotherapy. Despite this, there have been only a limited number of reports on the use of this family of molecules as gene-based adjuvants to enhance DNA and/or viral vector vaccines. In addition, the molecule latent membrane protein 1 (LMP1), a viral mimic of the TNF superfamily receptor CD40, provides an alternative approach for the design of novel molecular adjuvants. Here, we discuss advances in the development of recombinant TNF superfamily ligands as adjuvants for HIV vaccines and as cancer immunotherapy, including the use of LMP1 and LMP1-CD40 chimeric fusion proteins to mimic constitutive CD40 signaling.</description><subject>Adjuvants, Immunologic - chemistry</subject><subject>Allergology</subject><subject>Animals</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cancer Vaccines - chemistry</subject><subject>Cancer Vaccines - immunology</subject><subject>CD40 Antigens - immunology</subject><subject>CD40 Ligand - chemistry</subject><subject>CD40 Ligand - metabolism</subject><subject>Cells</subject><subject>Genetic Vectors - genetics</subject><subject>Genetic Vectors - immunology</subject><subject>Human immunodeficiency virus</subject><subject>Humans</subject><subject>Immune system</subject><subject>Immunology</subject><subject>Immunology & Microbiology in Miami</subject><subject>Immunotherapy</subject><subject>Internal Medicine</subject><subject>Lentivirus - genetics</subject><subject>Lentivirus - immunology</subject><subject>Ligands</subject><subject>Macaca mulatta</subject><subject>Medicine/Public Health</subject><subject>Molecular biology</subject><subject>Molecular Mimicry - immunology</subject><subject>Neoplasms - immunology</subject><subject>Neoplasms - therapy</subject><subject>Protein Multimerization</subject><subject>TNF-Related Apoptosis-Inducing Ligand - chemistry</subject><subject>Toll-Like Receptors - agonists</subject><subject>Tumor Necrosis Factors - chemistry</subject><subject>Vaccines</subject><subject>Vaccines - chemistry</subject><subject>Vaccines - immunology</subject><subject>Vaccines, Synthetic - chemistry</subject><subject>Vaccines, Synthetic - immunology</subject><subject>Viral Matrix Proteins - immunology</subject><issn>0257-277X</issn><issn>1559-0755</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkU1rFTEUhoNY7G31B7iRgJtuxp5MvmY2BemHCkU3FdyFNB9jLjPJbTJzof--udxaqiK4SSDvc96Tc16E3hL4QADkaSEttKIBQpuOMdqIF2hFOO8bkJy_RCtouWxaKX8coqNS1gBEVOwVOmwZ6TsQfIX8hSthiDh5vNXGhOiwtutlq-NccIgm5U3Keg5xwDdfr3BZNi57PYXxHo9h0NEWXI-_tCmNziyjzngKUzDlNTrweizuzeN9jL5fXd6cf26uv336cv7xujEc6Nxw8FZKb7nRdQzCeGeop5QBd07b285a6cDq-uydlx4oEdQT3nHgprcS6DE62_tultvJWePinPWoNjlMOt-rpIP6XYnhpxrSVtFe1J3RanDyaJDT3eLKrKZQjBtHHV1aiiKsbwWhHeP_gQopKGOMVPT9H-g6LTnWTewoQWVPe1kpsqdMTqVk55_-TUDtAlf7wFUNXO0CV6LWvHs-8FPFr4Qr0O6BUqU4uPys9T9dHwD57be8</recordid><startdate>20131201</startdate><enddate>20131201</enddate><creator>Gupta, Sachin</creator><creator>Termini, James M.</creator><creator>Kanagavelu, Saravana</creator><creator>Stone, Geoffrey W.</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20131201</creationdate><title>Design of vaccine adjuvants incorporating TNF superfamily ligands and TNF superfamily molecular mimics</title><author>Gupta, Sachin ; Termini, James M. ; Kanagavelu, Saravana ; Stone, Geoffrey W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c503t-50fd77fd5ca5591458c3f33405eeadb8dd7e0da58cfef7f03163f158505c9d703</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adjuvants, Immunologic - chemistry</topic><topic>Allergology</topic><topic>Animals</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cancer Vaccines - chemistry</topic><topic>Cancer Vaccines - immunology</topic><topic>CD40 Antigens - immunology</topic><topic>CD40 Ligand - chemistry</topic><topic>CD40 Ligand - metabolism</topic><topic>Cells</topic><topic>Genetic Vectors - genetics</topic><topic>Genetic Vectors - immunology</topic><topic>Human immunodeficiency virus</topic><topic>Humans</topic><topic>Immune system</topic><topic>Immunology</topic><topic>Immunology & Microbiology in Miami</topic><topic>Immunotherapy</topic><topic>Internal Medicine</topic><topic>Lentivirus - genetics</topic><topic>Lentivirus - immunology</topic><topic>Ligands</topic><topic>Macaca mulatta</topic><topic>Medicine/Public Health</topic><topic>Molecular biology</topic><topic>Molecular Mimicry - immunology</topic><topic>Neoplasms - immunology</topic><topic>Neoplasms - therapy</topic><topic>Protein Multimerization</topic><topic>TNF-Related Apoptosis-Inducing Ligand - chemistry</topic><topic>Toll-Like Receptors - agonists</topic><topic>Tumor Necrosis Factors - chemistry</topic><topic>Vaccines</topic><topic>Vaccines - chemistry</topic><topic>Vaccines - immunology</topic><topic>Vaccines, Synthetic - chemistry</topic><topic>Vaccines, Synthetic - immunology</topic><topic>Viral Matrix Proteins - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gupta, Sachin</creatorcontrib><creatorcontrib>Termini, James M.</creatorcontrib><creatorcontrib>Kanagavelu, Saravana</creatorcontrib><creatorcontrib>Stone, Geoffrey W.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Immunologic research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gupta, Sachin</au><au>Termini, James M.</au><au>Kanagavelu, Saravana</au><au>Stone, Geoffrey W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Design of vaccine adjuvants incorporating TNF superfamily ligands and TNF superfamily molecular mimics</atitle><jtitle>Immunologic research</jtitle><stitle>Immunol Res</stitle><addtitle>Immunol Res</addtitle><date>2013-12-01</date><risdate>2013</risdate><volume>57</volume><issue>1-3</issue><spage>303</spage><epage>310</epage><pages>303-310</pages><issn>0257-277X</issn><eissn>1559-0755</eissn><abstract>TNF superfamily ligands play a critical role in the regulation of adaptive immune responses, including the costimulation of dendritic cells, T cells, and B cells. This costimulation could potentially be exploited for the development of prophylactic vaccines and immunotherapy. Despite this, there have been only a limited number of reports on the use of this family of molecules as gene-based adjuvants to enhance DNA and/or viral vector vaccines. In addition, the molecule latent membrane protein 1 (LMP1), a viral mimic of the TNF superfamily receptor CD40, provides an alternative approach for the design of novel molecular adjuvants. Here, we discuss advances in the development of recombinant TNF superfamily ligands as adjuvants for HIV vaccines and as cancer immunotherapy, including the use of LMP1 and LMP1-CD40 chimeric fusion proteins to mimic constitutive CD40 signaling.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>24198065</pmid><doi>10.1007/s12026-013-8443-6</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adjuvants, Immunologic - chemistry Allergology Animals Biomedical and Life Sciences Biomedicine Cancer Vaccines - chemistry Cancer Vaccines - immunology CD40 Antigens - immunology CD40 Ligand - chemistry CD40 Ligand - metabolism Cells Genetic Vectors - genetics Genetic Vectors - immunology Human immunodeficiency virus Humans Immune system Immunology Immunology & Microbiology in Miami Immunotherapy Internal Medicine Lentivirus - genetics Lentivirus - immunology Ligands Macaca mulatta Medicine/Public Health Molecular biology Molecular Mimicry - immunology Neoplasms - immunology Neoplasms - therapy Protein Multimerization TNF-Related Apoptosis-Inducing Ligand - chemistry Toll-Like Receptors - agonists Tumor Necrosis Factors - chemistry Vaccines Vaccines - chemistry Vaccines - immunology Vaccines, Synthetic - chemistry Vaccines, Synthetic - immunology Viral Matrix Proteins - immunology |
| title | Design of vaccine adjuvants incorporating TNF superfamily ligands and TNF superfamily molecular mimics |
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