Dynamics of Blood Count after Rheohemapheresis in Age-Related Macular Degeneration : Possible Association with Clinical Changes
Background. Rheohemapheresis (RHF) is a method that can stop the activity of the dry form of age-related macular degeneration (AMD). The pathophysiologic mechanisms are not well understood, and the effects of the RHF procedures extend beyond the time of the individual procedures. Patients and Method...
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| Veröffentlicht in: | BioMed research international 2014-01, Vol.2014 (2014), p.1-5 |
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| creator | Bláha, Milan Košťál, Milan Rencová, Eva Lánská, Miriam Rozsíval, Pavel Kratochvilová, Vera Langrová, Hana |
| description | Background. Rheohemapheresis (RHF) is a method that can stop the activity of the dry form of age-related macular degeneration (AMD). The pathophysiologic mechanisms are not well understood, and the effects of the RHF procedures extend beyond the time of the individual procedures. Patients and Methods. We present the data for 46 patients with AMD treated with a series of 8 rheohemapheretic procedures. Blood count parameters were measured before the first and the last procedures. The clinical effect was judged by changes in the drusenoid pigment epithelium detachment (DPED) area before and after the rheopheretic sessions. Results. Rheopheresis caused a decrease in hemoglobin (P |
| doi_str_mv | 10.1155/2014/858219 |
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Rheohemapheresis (RHF) is a method that can stop the activity of the dry form of age-related macular degeneration (AMD). The pathophysiologic mechanisms are not well understood, and the effects of the RHF procedures extend beyond the time of the individual procedures. Patients and Methods. We present the data for 46 patients with AMD treated with a series of 8 rheohemapheretic procedures. Blood count parameters were measured before the first and the last procedures. The clinical effect was judged by changes in the drusenoid pigment epithelium detachment (DPED) area before and after the rheopheretic sessions. Results. Rheopheresis caused a decrease in hemoglobin (P<0.001), a decrease in leukocytes (P<0.034), and an increase in platelets (P<0.005). We found a negative correlation between the amount of platelets and their volume (P<0.001, Pearson correlation coefficient: −0.509). We identified the platelet/MPV ratio as a good predictor of the clinical outcome. Patients with a platelet/MPV ratio greater than 21.5 (before the last rheopheresis) had a significantly better outcome (P=0.003, sensitivity of 76.9% and specificity of 80%). Conclusion. Several basic blood count parameters after RHF can be concluded to significantly change, with some of those changes correlating with the clinical results (reduction of the DPED area).</description><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2014/858219</identifier><identifier>PMID: 24734249</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Puplishing Corporation</publisher><subject>Aged ; Aged, 80 and over ; Blood Cell Count ; Blood platelets ; Blood Platelets - cytology ; Cytapheresis - methods ; Diabetes ; Disease ; Female ; Hospitals ; Humans ; Laboratories ; Leukocytes - cytology ; Macular degeneration ; Macular Degeneration - therapy ; Male ; Middle Aged ; Molecular weight ; Patients ; Plasma ; Retinal Detachment - diagnosis ; Retinal Detachment - pathology ; Retinal Detachment - therapy ; Retinal Drusen - complications ; Retinal Drusen - therapy ; Treatment Outcome</subject><ispartof>BioMed research international, 2014-01, Vol.2014 (2014), p.1-5</ispartof><rights>Copyright © 2014 Milan Košťál et al.</rights><rights>Copyright © 2014 Milan Kostál et al. Milan Kostál et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2014 Milan Košťál et al. 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c466t-8fc1f6913e827faaf827fb8ac23854c74c235b55eb5d9465f50ed435b8dc43e13</citedby><cites>FETCH-LOGICAL-c466t-8fc1f6913e827faaf827fb8ac23854c74c235b55eb5d9465f50ed435b8dc43e13</cites><orcidid>0000-0001-8488-7208</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3966403/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3966403/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,882,27905,27906,53772,53774</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24734249$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Klein, Ronald L.</contributor><creatorcontrib>Bláha, Milan</creatorcontrib><creatorcontrib>Košťál, Milan</creatorcontrib><creatorcontrib>Rencová, Eva</creatorcontrib><creatorcontrib>Lánská, Miriam</creatorcontrib><creatorcontrib>Rozsíval, Pavel</creatorcontrib><creatorcontrib>Kratochvilová, Vera</creatorcontrib><creatorcontrib>Langrová, Hana</creatorcontrib><title>Dynamics of Blood Count after Rheohemapheresis in Age-Related Macular Degeneration : Possible Association with Clinical Changes</title><title>BioMed research international</title><addtitle>Biomed Res Int</addtitle><description>Background. Rheohemapheresis (RHF) is a method that can stop the activity of the dry form of age-related macular degeneration (AMD). The pathophysiologic mechanisms are not well understood, and the effects of the RHF procedures extend beyond the time of the individual procedures. Patients and Methods. We present the data for 46 patients with AMD treated with a series of 8 rheohemapheretic procedures. Blood count parameters were measured before the first and the last procedures. The clinical effect was judged by changes in the drusenoid pigment epithelium detachment (DPED) area before and after the rheopheretic sessions. Results. Rheopheresis caused a decrease in hemoglobin (P<0.001), a decrease in leukocytes (P<0.034), and an increase in platelets (P<0.005). We found a negative correlation between the amount of platelets and their volume (P<0.001, Pearson correlation coefficient: −0.509). We identified the platelet/MPV ratio as a good predictor of the clinical outcome. Patients with a platelet/MPV ratio greater than 21.5 (before the last rheopheresis) had a significantly better outcome (P=0.003, sensitivity of 76.9% and specificity of 80%). Conclusion. Several basic blood count parameters after RHF can be concluded to significantly change, with some of those changes correlating with the clinical results (reduction of the DPED area).</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Blood Cell Count</subject><subject>Blood platelets</subject><subject>Blood Platelets - cytology</subject><subject>Cytapheresis - methods</subject><subject>Diabetes</subject><subject>Disease</subject><subject>Female</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Laboratories</subject><subject>Leukocytes - cytology</subject><subject>Macular degeneration</subject><subject>Macular Degeneration - therapy</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Molecular weight</subject><subject>Patients</subject><subject>Plasma</subject><subject>Retinal Detachment - diagnosis</subject><subject>Retinal Detachment - pathology</subject><subject>Retinal Detachment - therapy</subject><subject>Retinal Drusen - 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cytology</topic><topic>Cytapheresis - methods</topic><topic>Diabetes</topic><topic>Disease</topic><topic>Female</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Laboratories</topic><topic>Leukocytes - cytology</topic><topic>Macular degeneration</topic><topic>Macular Degeneration - therapy</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Molecular weight</topic><topic>Patients</topic><topic>Plasma</topic><topic>Retinal Detachment - diagnosis</topic><topic>Retinal Detachment - pathology</topic><topic>Retinal Detachment - therapy</topic><topic>Retinal Drusen - complications</topic><topic>Retinal Drusen - therapy</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bláha, Milan</creatorcontrib><creatorcontrib>Košťál, Milan</creatorcontrib><creatorcontrib>Rencová, Eva</creatorcontrib><creatorcontrib>Lánská, Miriam</creatorcontrib><creatorcontrib>Rozsíval, Pavel</creatorcontrib><creatorcontrib>Kratochvilová, Vera</creatorcontrib><creatorcontrib>Langrová, Hana</creatorcontrib><collection>الدوريات العلمية والإحصائية - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BioMed research international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bláha, Milan</au><au>Košťál, Milan</au><au>Rencová, Eva</au><au>Lánská, Miriam</au><au>Rozsíval, Pavel</au><au>Kratochvilová, Vera</au><au>Langrová, Hana</au><au>Klein, Ronald L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dynamics of Blood Count after Rheohemapheresis in Age-Related Macular Degeneration : Possible Association with Clinical Changes</atitle><jtitle>BioMed research international</jtitle><addtitle>Biomed Res Int</addtitle><date>2014-01-01</date><risdate>2014</risdate><volume>2014</volume><issue>2014</issue><spage>1</spage><epage>5</epage><pages>1-5</pages><issn>2314-6133</issn><eissn>2314-6141</eissn><abstract>Background. Rheohemapheresis (RHF) is a method that can stop the activity of the dry form of age-related macular degeneration (AMD). The pathophysiologic mechanisms are not well understood, and the effects of the RHF procedures extend beyond the time of the individual procedures. Patients and Methods. We present the data for 46 patients with AMD treated with a series of 8 rheohemapheretic procedures. Blood count parameters were measured before the first and the last procedures. The clinical effect was judged by changes in the drusenoid pigment epithelium detachment (DPED) area before and after the rheopheretic sessions. Results. Rheopheresis caused a decrease in hemoglobin (P<0.001), a decrease in leukocytes (P<0.034), and an increase in platelets (P<0.005). We found a negative correlation between the amount of platelets and their volume (P<0.001, Pearson correlation coefficient: −0.509). We identified the platelet/MPV ratio as a good predictor of the clinical outcome. Patients with a platelet/MPV ratio greater than 21.5 (before the last rheopheresis) had a significantly better outcome (P=0.003, sensitivity of 76.9% and specificity of 80%). Conclusion. Several basic blood count parameters after RHF can be concluded to significantly change, with some of those changes correlating with the clinical results (reduction of the DPED area).</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Puplishing Corporation</pub><pmid>24734249</pmid><doi>10.1155/2014/858219</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0001-8488-7208</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Aged, 80 and over Blood Cell Count Blood platelets Blood Platelets - cytology Cytapheresis - methods Diabetes Disease Female Hospitals Humans Laboratories Leukocytes - cytology Macular degeneration Macular Degeneration - therapy Male Middle Aged Molecular weight Patients Plasma Retinal Detachment - diagnosis Retinal Detachment - pathology Retinal Detachment - therapy Retinal Drusen - complications Retinal Drusen - therapy Treatment Outcome |
| title | Dynamics of Blood Count after Rheohemapheresis in Age-Related Macular Degeneration : Possible Association with Clinical Changes |
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