Aurora A is a negative prognostic factor and a new therapeutic target in human neuroblastoma

We studied expression of the Aurora A gene and its clinical significance in a cohort of neuroblastoma patients. In addition, we investigated the antitumor activity of MLN8054, a novel small-molecule inhibitor of Aurora A kinase, on cultured NB cell lines in vitro. Aurora A mRNA expression was assess...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Molecular cancer therapeutics 2009-08, Vol.8 (8), p.2461-2469
Hauptverfasser:	Shang, Xiaoying, Burlingame, Susan M, Okcu, M Fatih, Ge, Ningling, Russell, Heidi V, Egler, Rachel A, David, Rodney D, Vasudevan, Sanjeev A, Yang, Jianhua, Nuchtern, Jed G
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - pharmacology Apoptosis Aurora A Aurora Kinases Benzazepines - pharmacology Cell Line, Tumor Cell Proliferation Cohort Studies Humans MLN8054 inhibitor neuroblastoma Neuroblastoma - diagnosis Neuroblastoma - drug therapy Neuroblastoma - enzymology Prognosis Protein-Serine-Threonine Kinases - antagonists & inhibitors Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism RNA, Messenger - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!