The Three-Dimensional Structure of the Biotin Carboxylase-Biotin Carboxyl Carrier Protein Complex of E. coli Acetyl-CoA Carboxylase

Acetyl-coenzyme A (acetyl-CoA) carboxylase is a biotin-dependent, multifunctional enzyme that catalyzes the regulated step in fatty acid synthesis. The Escherichia coli enzyme is composed of a homodimeric biotin carboxylase (BC), biotinylated biotin carboxyl carrier protein (BCCP), and an α2β2 heter...

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Veröffentlicht in:	Structure 2013-04, Vol.21 (4), p.650-657
Hauptverfasser:	Broussard, Tyler C., Kobe, Matthew J., Pakhomova, Svetlana, Neau, David B., Price, Amanda E., Champion, Tyler S., Waldrop, Grover L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetyl-CoA Carboxylase - chemistry Bacteria Biotin Carbon-Nitrogen Ligases - chemistry Carriers Crystallization Enzymes Escherichia coli Escherichia coli - enzymology Fatty Acid Synthase, Type II - chemistry Fatty acids Models, Molecular Multiprotein Complexes - chemistry Protein Conformation Proteins Three dimensional X-Ray Diffraction
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