Novel curcumin-loaded magnetic nanoparticles for pancreatic cancer treatment

Curcumin (CUR), a naturally occurring polyphenol derived from the root of Curcuma longa, has showed potent anticancer and cancer prevention activity in a variety of cancers. However, the clinical translation of CUR has been significantly hampered due to its extensive degradation, suboptimal pharmaco...

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Veröffentlicht in:	Molecular cancer therapeutics 2013-08, Vol.12 (8), p.1471-1480
Hauptverfasser:	Yallapu, Murali M, Ebeling, Mara C, Khan, Sheema, Sundram, Vasudha, Chauhan, Neeraj, Gupta, Brij K, Puumala, Susan E, Jaggi, Meena, Chauhan, Subhash C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - administration & dosage Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Biological Availability Blood Proteins - metabolism Cell Line, Tumor Cell Proliferation - drug effects Chemistry, Pharmaceutical Curcumin - administration & dosage Curcumin - chemistry Curcumin - pharmacology Disease Models, Animal Drug Carriers Drug Delivery Systems Erythrocytes - drug effects Erythrocytes - metabolism Humans Magnetite Nanoparticles - chemistry Male Mice Pancreatic Neoplasms - drug therapy Pancreatic Neoplasms - mortality Pancreatic Neoplasms - pathology Protein Binding Tissue Distribution Tumor Burden - drug effects Tumor Stem Cell Assay Xenograft Model Antitumor Assays
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