Genetic and epigenetic regulation of AHR gene expression in MCF-7 breast cancer cells: Role of the proximal promoter GC-rich region

The aryl hydrocarbon receptor (AhR), a ligand-activated transcription factor, contributes to carcinogenesis through its role in the regulation of cytochrome P450 1 (CYP1)-catalyzed metabolism of carcinogens. Here, we investigated genetic and epigenetic mechanisms that affect AhR expression. Analyses...

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Veröffentlicht in:	Biochemical pharmacology 2012-09, Vol.84 (5), p.722-735
Hauptverfasser:	Englert, Neal A., Turesky, Robert J., Han, Weiguo, Bessette, Erin E., Spivack, Simon D., Caggana, Michele, Spink, David C., Spink, Barbara C.
Format:	Artikel
Sprache:	eng
Schlagworte:	(GGGGC)n repeat polymorphism 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine AhR gene Aryl hydrocarbon receptor Aryl hydrocarbon receptors Breast cancer breast neoplasms C.D Carcinogenesis Carcinogens Cell Line, Tumor Chromatin Chromatin Immunoprecipitation Chromatography, Liquid Circular Dichroism circular dichroism spectroscopy cytochrome P-450 Cytochrome P-450 CYP1A1 - metabolism Cytochrome P450 DNA adducts DNA methylation electrophoresis Electrophoretic mobility Electrophoretic Mobility Shift Assay Epigenesis, Genetic Epigenetic epigenetics Estrogens GC Rich Sequence gene expression Gene Expression Regulation, Neoplastic Gene frequency Guanine-quadruplex Histones Humans Immunoprecipitation Long-term estrogen exposure luciferase Lysine Metabolism Methylation mRNA stability Mutagenesis, Site-Directed Neonates pharmacology Population genetics precipitin tests promoter regions Promoter Regions, Genetic Promoters pyridines Real-Time Polymerase Chain Reaction Receptors, Aryl Hydrocarbon - genetics RNA RNA processing Sp Transcription Factors - metabolism Spectrometry, Mass, Electrospray Ionization Spectroscopy Transcription factors
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