Inflammatory bowel disease of primary sclerosing cholangitis:A distinct entity?
This is a review of the characteristic findings of inflammatory bowel disease(IBD)associated with primary sclerosing cholangitis(PSC)and their usefulness in the diagnosis of sclerosing cholangitis.PSC is a chronic inflammatory disease characterized by idiopathic fibrous obstruction and is frequently...
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| Veröffentlicht in: | World journal of gastroenterology : WJG 2014-03, Vol.20 (12), p.3245-3254 |
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| container_title | World journal of gastroenterology : WJG |
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| creator | Nakazawa, Takahiro Naitoh, Itaru Hayashi, Kazuki Sano, Hitoshi Miyabe, Katsuyuki Shimizu, Shuya Joh, Takashi |
| description | This is a review of the characteristic findings of inflammatory bowel disease(IBD)associated with primary sclerosing cholangitis(PSC)and their usefulness in the diagnosis of sclerosing cholangitis.PSC is a chronic inflammatory disease characterized by idiopathic fibrous obstruction and is frequently associated with IBD.IBDassociated with PSC(PSC-IBD)shows an increased incidence of pancolitis,mild symptoms,and colorectal malignancy.Although an increased incidence of pancolitis is a characteristic finding,some cases are endoscopically diagnosed as right-sided ulcerative colitis.Pathological studies have revealed that inflammation occurs more frequently in the right colon than the left colon.The frequency of rectal sparing and backwash ileitis should be investigated in a future study based on the same definition.The cholangiographic findings of immunoglobulin G4-related sclerosing cholangitis(IgG4-SC)are similar to those of PSC.The rare association between IBD and IgG4-SC and the unique characteristics of PSC-IBD are useful findings for distinguishing PSC from IgG4-SC. |
| doi_str_mv | 10.3748/wjg.v20.i12.3245 |
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| source | MEDLINE; Baishideng "World Journal of" online journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | bowel cholangitis Cholangitis, Sclerosing - diagnosis Cholangitis, Sclerosing - pathology Colitis - pathology Colitis, Ulcerative - diagnosis Colitis, Ulcerative - pathology Colon - pathology Colonoscopy Colorectal Neoplasms - complications Colorectal Neoplasms - pathology Diagnosis, Differential Humans Immunoglobulin G - blood Inflammation Inflammatory Inflammatory Bowel Diseases - diagnosis Inflammatory Bowel Diseases - pathology Primary sclerosing Topic Highlight Treatment Outcome |
| title | Inflammatory bowel disease of primary sclerosing cholangitis:A distinct entity? |
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