Understanding the antagonism of retinoblastoma protein dephosphorylation by PNUTS provides insights into the PP1 regulatory code

The serine/threonine protein phosphatase 1 (PP1) dephosphorylates hundreds of key biological targets by associating with nearly 200 regulatory proteins to form highly specific holoenzymes. However, how these proteins direct PP1 specificity and the ability to predict how these PP1 interacting protein...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2014-03, Vol.111 (11), p.4097-4102
Hauptverfasser:	Choy, Meng S., Hieke, Martina, Kumar, Ganesan Senthil, Lewis, Greyson R., Gonzalez-DeWhitt, Kristofer R., Kessler, Rene P., Stein, Benjamin J., Hessenberger, Manuel, Nairn, Angus C., Peti, Wolfgang, Page, Rebecca
Format:	Artikel
Sprache:	eng
Schlagworte:	Active sites Amino Acid Sequence Amino acids Biological Sciences Biophysics Calorimetry Cancer Chromatin Assembly and Disassembly - physiology Cloning, Molecular Computational Biology Crystallization DNA-Binding Proteins - chemistry DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Drug regulation Enzymes Gene expression regulation Gene Expression Regulation, Enzymologic - genetics Humans Magnetic Resonance Spectroscopy Models, Molecular Molecular Sequence Data Nuclear Proteins - chemistry Nuclear Proteins - genetics Nuclear Proteins - metabolism Phosphatases Phosphorylation Physiological regulation Protein Conformation Protein Interaction Domains and Motifs - genetics Protein Phosphatase 1 - chemistry Protein Phosphatase 1 - genetics Protein Phosphatase 1 - metabolism Proteins Proto-Oncogene Proteins c-mdm2 - metabolism Regulator genes Retinoblastoma Protein - metabolism RNA-Binding Proteins - chemistry RNA-Binding Proteins - genetics RNA-Binding Proteins - metabolism Sequence Alignment Substrate Specificity
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