Association of plasma selenium concentrations with total IGF-1 among older community-dwelling adults: The InCHIANTI study
Summary Background & aims Insulin-like growth factor (IGF-1) stimulates cell proliferation and inhibits cell apoptosis. Recent studies underline its importance as anabolic hormone and nutritional marker in older individuals. IGF-1 synthesis and bioactivity are modulated by nutritional factors in...
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| Veröffentlicht in: | Clinical nutrition (Edinburgh, Scotland) Scotland), 2010-10, Vol.29 (5), p.674-677 |
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| creator | Maggio, Marcello Ceda, Gian Paolo Lauretani, Fulvio Bandinelli, Stefania Dall’Aglio, Elisabetta Guralnik, Jack M Paolisso, Giuseppe Semba, Richard D Nouvenne, Antonio Borghi, Loris Ceresini, Graziano Ablondi, Fabrizio Benatti, Mario Ferrucci, Luigi |
| description | Summary Background & aims Insulin-like growth factor (IGF-1) stimulates cell proliferation and inhibits cell apoptosis. Recent studies underline its importance as anabolic hormone and nutritional marker in older individuals. IGF-1 synthesis and bioactivity are modulated by nutritional factors including selenium intake. However, whether circulating IGF-1 levels are positively influenced by plasma selenium, one of the most important human antioxidants, is still unknown. Methods Selenium and total IGF-1 were measured in 951 men and women ≥ 65 years from the InCHIANTI study, Tuscany, Italy. Results Means (SD) of plasma selenium and total IGF-1 were 0.95 (0.15) μmol/L and 113.4 (31.2) ng/mL, respectively. After adjustment for age and sex, selenium levels were positively associated with total IGF-1 ( β ± SE: 43.76 ± 11.2, p = 0.0001). After further adjustment for total energy and alcohol intake, serum alanine aminotransferase (ALT), congestive heart failure, selenium remained significantly associated with IGF-1 ( β ± SE: 36.7 ± 12.2, p = 0.003). The association was still significant when IL-6 was introduced in the model ( β ± SE: 40.1 ± 12.0, p = 0.0008). Conclusions We found an independent, positive and significant association between selenium and IGF-1 serum levels in community dwelling older adults. |
| doi_str_mv | 10.1016/j.clnu.2010.03.012 |
| format | Article |
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Recent studies underline its importance as anabolic hormone and nutritional marker in older individuals. IGF-1 synthesis and bioactivity are modulated by nutritional factors including selenium intake. However, whether circulating IGF-1 levels are positively influenced by plasma selenium, one of the most important human antioxidants, is still unknown. Methods Selenium and total IGF-1 were measured in 951 men and women ≥ 65 years from the InCHIANTI study, Tuscany, Italy. Results Means (SD) of plasma selenium and total IGF-1 were 0.95 (0.15) μmol/L and 113.4 (31.2) ng/mL, respectively. After adjustment for age and sex, selenium levels were positively associated with total IGF-1 ( β ± SE: 43.76 ± 11.2, p = 0.0001). After further adjustment for total energy and alcohol intake, serum alanine aminotransferase (ALT), congestive heart failure, selenium remained significantly associated with IGF-1 ( β ± SE: 36.7 ± 12.2, p = 0.003). The association was still significant when IL-6 was introduced in the model ( β ± SE: 40.1 ± 12.0, p = 0.0008). Conclusions We found an independent, positive and significant association between selenium and IGF-1 serum levels in community dwelling older adults.</description><identifier>ISSN: 0261-5614</identifier><identifier>EISSN: 1532-1983</identifier><identifier>DOI: 10.1016/j.clnu.2010.03.012</identifier><identifier>PMID: 20416996</identifier><identifier>CODEN: CLNUDP</identifier><language>eng</language><publisher>Kidlington: Elsevier Ltd</publisher><subject>Aged ; Aged, 80 and over ; Aging ; Aging - physiology ; Biological and medical sciences ; Cross-Sectional Studies ; Energy Intake ; Feeding. Feeding behavior ; Female ; Fundamental and applied biological sciences. Psychology ; Gastroenterology and Hepatology ; Humans ; Insulin-Like Growth Factor I - metabolism ; Italy ; Male ; Residence Characteristics ; Selenium ; Selenium - blood ; Selenium - metabolism ; Total IGF-1 ; Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><ispartof>Clinical nutrition (Edinburgh, Scotland), 2010-10, Vol.29 (5), p.674-677</ispartof><rights>Elsevier Ltd and European Society for Clinical Nutrition and Metabolism</rights><rights>2010 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2010 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.</rights><rights>2010 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved. 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c539t-73d930ace8f8392fc3825379a80525b0cd879d21476729589dc25c4b167074c33</citedby><cites>FETCH-LOGICAL-c539t-73d930ace8f8392fc3825379a80525b0cd879d21476729589dc25c4b167074c33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.clnu.2010.03.012$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,777,781,882,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23348012$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20416996$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Maggio, Marcello</creatorcontrib><creatorcontrib>Ceda, Gian Paolo</creatorcontrib><creatorcontrib>Lauretani, Fulvio</creatorcontrib><creatorcontrib>Bandinelli, Stefania</creatorcontrib><creatorcontrib>Dall’Aglio, Elisabetta</creatorcontrib><creatorcontrib>Guralnik, Jack M</creatorcontrib><creatorcontrib>Paolisso, Giuseppe</creatorcontrib><creatorcontrib>Semba, Richard D</creatorcontrib><creatorcontrib>Nouvenne, Antonio</creatorcontrib><creatorcontrib>Borghi, Loris</creatorcontrib><creatorcontrib>Ceresini, Graziano</creatorcontrib><creatorcontrib>Ablondi, Fabrizio</creatorcontrib><creatorcontrib>Benatti, Mario</creatorcontrib><creatorcontrib>Ferrucci, Luigi</creatorcontrib><title>Association of plasma selenium concentrations with total IGF-1 among older community-dwelling adults: The InCHIANTI study</title><title>Clinical nutrition (Edinburgh, Scotland)</title><addtitle>Clin Nutr</addtitle><description>Summary Background & aims Insulin-like growth factor (IGF-1) stimulates cell proliferation and inhibits cell apoptosis. Recent studies underline its importance as anabolic hormone and nutritional marker in older individuals. IGF-1 synthesis and bioactivity are modulated by nutritional factors including selenium intake. However, whether circulating IGF-1 levels are positively influenced by plasma selenium, one of the most important human antioxidants, is still unknown. Methods Selenium and total IGF-1 were measured in 951 men and women ≥ 65 years from the InCHIANTI study, Tuscany, Italy. Results Means (SD) of plasma selenium and total IGF-1 were 0.95 (0.15) μmol/L and 113.4 (31.2) ng/mL, respectively. After adjustment for age and sex, selenium levels were positively associated with total IGF-1 ( β ± SE: 43.76 ± 11.2, p = 0.0001). After further adjustment for total energy and alcohol intake, serum alanine aminotransferase (ALT), congestive heart failure, selenium remained significantly associated with IGF-1 ( β ± SE: 36.7 ± 12.2, p = 0.003). The association was still significant when IL-6 was introduced in the model ( β ± SE: 40.1 ± 12.0, p = 0.0008). Conclusions We found an independent, positive and significant association between selenium and IGF-1 serum levels in community dwelling older adults.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aging</subject><subject>Aging - physiology</subject><subject>Biological and medical sciences</subject><subject>Cross-Sectional Studies</subject><subject>Energy Intake</subject><subject>Feeding. Feeding behavior</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gastroenterology and Hepatology</subject><subject>Humans</subject><subject>Insulin-Like Growth Factor I - metabolism</subject><subject>Italy</subject><subject>Male</subject><subject>Residence Characteristics</subject><subject>Selenium</subject><subject>Selenium - blood</subject><subject>Selenium - metabolism</subject><subject>Total IGF-1</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><issn>0261-5614</issn><issn>1532-1983</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kstuEzEUQEcIREPhB1ggb1BXE_yYh41QpSiibaQKFoS15diexsFjB9vTav4eDxPKY8HKkn3uy-cWxWsElwii5t1hKa0blhjmC0iWEOEnxQLVBJeIUfK0WEDcoLJuUHVWvIjxACGsSUufF2cYVqhhrFkU4ypGL41IxjvgO3C0IvYCRG21M0MPpHdSuxR-AhE8mLQHySdhweb6qkRA9N7dAW-VDpnt-8GZNJbqQVtr8oNQg03xPdjuNdi49c1m9Wm7ATENanxZPOuEjfrV6Twvvl593K5vytvP15v16raUNWGpbIliBAqpaUcJw50kFOcpmKCwxvUOSkVbpjCq2qbFrKZMSVzLaoeaFraVJOS8uJzzHoddr9U8jeXHYHoRRu6F4X-_OLPnd_6eE9aQhtU5wcUpQfDfBx0T702UeUDhtB8ib-u2anAFaSbxTMrgYwy6e6yCIJ-U8QOflPFJGYeEZ2U56M2f_T2G_HKUgbcnQEQpbBeEkyb-5gip6Jzow8zp_Jv3RgcepdFZnzJBy8SVN__v4_KfcJkVmlzxmx51PPghuOyJIx4xh_zLtFzTbqG8VrBFhPwA4DTKcg</recordid><startdate>20101001</startdate><enddate>20101001</enddate><creator>Maggio, Marcello</creator><creator>Ceda, Gian Paolo</creator><creator>Lauretani, Fulvio</creator><creator>Bandinelli, Stefania</creator><creator>Dall’Aglio, Elisabetta</creator><creator>Guralnik, Jack M</creator><creator>Paolisso, Giuseppe</creator><creator>Semba, Richard D</creator><creator>Nouvenne, Antonio</creator><creator>Borghi, Loris</creator><creator>Ceresini, Graziano</creator><creator>Ablondi, Fabrizio</creator><creator>Benatti, Mario</creator><creator>Ferrucci, Luigi</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20101001</creationdate><title>Association of plasma selenium concentrations with total IGF-1 among older community-dwelling adults: The InCHIANTI study</title><author>Maggio, Marcello ; Ceda, Gian Paolo ; Lauretani, Fulvio ; Bandinelli, Stefania ; Dall’Aglio, Elisabetta ; Guralnik, Jack M ; Paolisso, Giuseppe ; Semba, Richard D ; Nouvenne, Antonio ; Borghi, Loris ; Ceresini, Graziano ; Ablondi, Fabrizio ; Benatti, Mario ; Ferrucci, Luigi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c539t-73d930ace8f8392fc3825379a80525b0cd879d21476729589dc25c4b167074c33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Aging</topic><topic>Aging - physiology</topic><topic>Biological and medical sciences</topic><topic>Cross-Sectional Studies</topic><topic>Energy Intake</topic><topic>Feeding. Feeding behavior</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gastroenterology and Hepatology</topic><topic>Humans</topic><topic>Insulin-Like Growth Factor I - metabolism</topic><topic>Italy</topic><topic>Male</topic><topic>Residence Characteristics</topic><topic>Selenium</topic><topic>Selenium - blood</topic><topic>Selenium - metabolism</topic><topic>Total IGF-1</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Maggio, Marcello</creatorcontrib><creatorcontrib>Ceda, Gian Paolo</creatorcontrib><creatorcontrib>Lauretani, Fulvio</creatorcontrib><creatorcontrib>Bandinelli, Stefania</creatorcontrib><creatorcontrib>Dall’Aglio, Elisabetta</creatorcontrib><creatorcontrib>Guralnik, Jack M</creatorcontrib><creatorcontrib>Paolisso, Giuseppe</creatorcontrib><creatorcontrib>Semba, Richard D</creatorcontrib><creatorcontrib>Nouvenne, Antonio</creatorcontrib><creatorcontrib>Borghi, Loris</creatorcontrib><creatorcontrib>Ceresini, Graziano</creatorcontrib><creatorcontrib>Ablondi, Fabrizio</creatorcontrib><creatorcontrib>Benatti, Mario</creatorcontrib><creatorcontrib>Ferrucci, Luigi</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Clinical nutrition (Edinburgh, Scotland)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Maggio, Marcello</au><au>Ceda, Gian Paolo</au><au>Lauretani, Fulvio</au><au>Bandinelli, Stefania</au><au>Dall’Aglio, Elisabetta</au><au>Guralnik, Jack M</au><au>Paolisso, Giuseppe</au><au>Semba, Richard D</au><au>Nouvenne, Antonio</au><au>Borghi, Loris</au><au>Ceresini, Graziano</au><au>Ablondi, Fabrizio</au><au>Benatti, Mario</au><au>Ferrucci, Luigi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of plasma selenium concentrations with total IGF-1 among older community-dwelling adults: The InCHIANTI study</atitle><jtitle>Clinical nutrition (Edinburgh, Scotland)</jtitle><addtitle>Clin Nutr</addtitle><date>2010-10-01</date><risdate>2010</risdate><volume>29</volume><issue>5</issue><spage>674</spage><epage>677</epage><pages>674-677</pages><issn>0261-5614</issn><eissn>1532-1983</eissn><coden>CLNUDP</coden><abstract>Summary Background & aims Insulin-like growth factor (IGF-1) stimulates cell proliferation and inhibits cell apoptosis. Recent studies underline its importance as anabolic hormone and nutritional marker in older individuals. IGF-1 synthesis and bioactivity are modulated by nutritional factors including selenium intake. However, whether circulating IGF-1 levels are positively influenced by plasma selenium, one of the most important human antioxidants, is still unknown. Methods Selenium and total IGF-1 were measured in 951 men and women ≥ 65 years from the InCHIANTI study, Tuscany, Italy. Results Means (SD) of plasma selenium and total IGF-1 were 0.95 (0.15) μmol/L and 113.4 (31.2) ng/mL, respectively. After adjustment for age and sex, selenium levels were positively associated with total IGF-1 ( β ± SE: 43.76 ± 11.2, p = 0.0001). After further adjustment for total energy and alcohol intake, serum alanine aminotransferase (ALT), congestive heart failure, selenium remained significantly associated with IGF-1 ( β ± SE: 36.7 ± 12.2, p = 0.003). The association was still significant when IL-6 was introduced in the model ( β ± SE: 40.1 ± 12.0, p = 0.0008). Conclusions We found an independent, positive and significant association between selenium and IGF-1 serum levels in community dwelling older adults.</abstract><cop>Kidlington</cop><pub>Elsevier Ltd</pub><pmid>20416996</pmid><doi>10.1016/j.clnu.2010.03.012</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Clinical nutrition (Edinburgh, Scotland), 2010-10, Vol.29 (5), p.674-677 |
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| subjects | Aged Aged, 80 and over Aging Aging - physiology Biological and medical sciences Cross-Sectional Studies Energy Intake Feeding. Feeding behavior Female Fundamental and applied biological sciences. Psychology Gastroenterology and Hepatology Humans Insulin-Like Growth Factor I - metabolism Italy Male Residence Characteristics Selenium Selenium - blood Selenium - metabolism Total IGF-1 Vertebrates: anatomy and physiology, studies on body, several organs or systems |
| title | Association of plasma selenium concentrations with total IGF-1 among older community-dwelling adults: The InCHIANTI study |
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