Characterizing the Collagen Fiber Orientation in Pericardial Leaflets Under Mechanical Loading Conditions
When implanted inside the body, bioprosthetic heart valve leaflets experience a variety of cyclic mechanical stresses such as shear stress due to blood flow when the valve is open, flexural stress due to cyclic opening and closure of the valve, and tensile stress when the valve is closed. These type...
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| Veröffentlicht in: | Annals of biomedical engineering 2013-03, Vol.41 (3), p.547-561 |
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| creator | Alavi, S. Hamed Ruiz, Victor Krasieva, Tatiana Botvinick, Elliot L. Kheradvar, Arash |
| description | When implanted inside the body, bioprosthetic heart valve leaflets experience a variety of cyclic mechanical stresses such as shear stress due to blood flow when the valve is open, flexural stress due to cyclic opening and closure of the valve, and tensile stress when the valve is closed. These types of stress lead to a variety of failure modes. In either a natural valve leaflet or a processed pericardial tissue leaflet, collagen fibers reinforce the tissue and provide structural integrity such that the very thin leaflet can stand enormous loads related to cyclic pressure changes. The mechanical response of the leaflet tissue greatly depends on collagen fiber concentration, characteristics, and orientation. Thus, understating the microstructure of pericardial tissue and its response to dynamic loading is crucial for the development of more durable heart valve, and computational models to predict heart valves' behavior. In this work, we have characterized the 3D collagen fiber arrangement of bovine pericardial tissue leaflets in response to a variety of different loading conditions under Second-Harmonic Generation Microscopy. This real-time visualization method assists in better understanding of the effect of cyclic load on collagen fiber orientation in time and space. |
| doi_str_mv | 10.1007/s10439-012-0696-z |
| format | Article |
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Hamed ; Ruiz, Victor ; Krasieva, Tatiana ; Botvinick, Elliot L. ; Kheradvar, Arash</creator><creatorcontrib>Alavi, S. Hamed ; Ruiz, Victor ; Krasieva, Tatiana ; Botvinick, Elliot L. ; Kheradvar, Arash</creatorcontrib><description>When implanted inside the body, bioprosthetic heart valve leaflets experience a variety of cyclic mechanical stresses such as shear stress due to blood flow when the valve is open, flexural stress due to cyclic opening and closure of the valve, and tensile stress when the valve is closed. These types of stress lead to a variety of failure modes. In either a natural valve leaflet or a processed pericardial tissue leaflet, collagen fibers reinforce the tissue and provide structural integrity such that the very thin leaflet can stand enormous loads related to cyclic pressure changes. The mechanical response of the leaflet tissue greatly depends on collagen fiber concentration, characteristics, and orientation. Thus, understating the microstructure of pericardial tissue and its response to dynamic loading is crucial for the development of more durable heart valve, and computational models to predict heart valves' behavior. In this work, we have characterized the 3D collagen fiber arrangement of bovine pericardial tissue leaflets in response to a variety of different loading conditions under Second-Harmonic Generation Microscopy. This real-time visualization method assists in better understanding of the effect of cyclic load on collagen fiber orientation in time and space.</description><identifier>ISSN: 0090-6964</identifier><identifier>EISSN: 1573-9686</identifier><identifier>DOI: 10.1007/s10439-012-0696-z</identifier><identifier>PMID: 23180029</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Animals ; Biochemistry ; Biological and Medical Physics ; Biomechanical Phenomena ; Biomedical and Life Sciences ; Biomedical Engineering - instrumentation ; Biomedical Engineering and Bioengineering ; Biomedicine ; Biophysics ; Bioprosthesis ; Cattle ; Classical Mechanics ; Collagen - chemistry ; Collagen - physiology ; Equipment Failure Analysis - instrumentation ; Fibers ; Heart Valve Prosthesis ; Humans ; Models, Cardiovascular ; Pericardium - chemistry ; Pericardium - physiology ; Shear stress ; Stress, Mechanical ; Tensile stress ; Tissues</subject><ispartof>Annals of biomedical engineering, 2013-03, Vol.41 (3), p.547-561</ispartof><rights>Biomedical Engineering Society 2012</rights><rights>Biomedical Engineering Society 2013</rights><rights>2012 Biomedical Engineering Society 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c503t-f440d109845fe9b5b6bab034216a412af0ccf47b1e1e33799e598eedd7e4ff0b3</citedby><cites>FETCH-LOGICAL-c503t-f440d109845fe9b5b6bab034216a412af0ccf47b1e1e33799e598eedd7e4ff0b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10439-012-0696-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10439-012-0696-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,780,784,885,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23180029$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Alavi, S. Hamed</creatorcontrib><creatorcontrib>Ruiz, Victor</creatorcontrib><creatorcontrib>Krasieva, Tatiana</creatorcontrib><creatorcontrib>Botvinick, Elliot L.</creatorcontrib><creatorcontrib>Kheradvar, Arash</creatorcontrib><title>Characterizing the Collagen Fiber Orientation in Pericardial Leaflets Under Mechanical Loading Conditions</title><title>Annals of biomedical engineering</title><addtitle>Ann Biomed Eng</addtitle><addtitle>Ann Biomed Eng</addtitle><description>When implanted inside the body, bioprosthetic heart valve leaflets experience a variety of cyclic mechanical stresses such as shear stress due to blood flow when the valve is open, flexural stress due to cyclic opening and closure of the valve, and tensile stress when the valve is closed. These types of stress lead to a variety of failure modes. In either a natural valve leaflet or a processed pericardial tissue leaflet, collagen fibers reinforce the tissue and provide structural integrity such that the very thin leaflet can stand enormous loads related to cyclic pressure changes. The mechanical response of the leaflet tissue greatly depends on collagen fiber concentration, characteristics, and orientation. Thus, understating the microstructure of pericardial tissue and its response to dynamic loading is crucial for the development of more durable heart valve, and computational models to predict heart valves' behavior. In this work, we have characterized the 3D collagen fiber arrangement of bovine pericardial tissue leaflets in response to a variety of different loading conditions under Second-Harmonic Generation Microscopy. This real-time visualization method assists in better understanding of the effect of cyclic load on collagen fiber orientation in time and space.</description><subject>Animals</subject><subject>Biochemistry</subject><subject>Biological and Medical Physics</subject><subject>Biomechanical Phenomena</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedical Engineering - instrumentation</subject><subject>Biomedical Engineering and Bioengineering</subject><subject>Biomedicine</subject><subject>Biophysics</subject><subject>Bioprosthesis</subject><subject>Cattle</subject><subject>Classical Mechanics</subject><subject>Collagen - chemistry</subject><subject>Collagen - physiology</subject><subject>Equipment Failure Analysis - instrumentation</subject><subject>Fibers</subject><subject>Heart Valve Prosthesis</subject><subject>Humans</subject><subject>Models, Cardiovascular</subject><subject>Pericardium - chemistry</subject><subject>Pericardium - physiology</subject><subject>Shear stress</subject><subject>Stress, Mechanical</subject><subject>Tensile stress</subject><subject>Tissues</subject><issn>0090-6964</issn><issn>1573-9686</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkU9v1DAQxS1ERZfCB-CCInHhEjr-kzi-IKGIAtJW5UDPluOMd11l7WJnK7GfHkdbqoKEevLh_d7zzDxC3lD4QAHkeaYguKqBshpa1daHZ2RFG8lr1Xbtc7ICUFAXQZySlznfAFDa8eYFOWWcdgBMrYjvtyYZO2PyBx821bzFqo_TZDYYqgs_YKqukscwm9nHUPlQfS-oNWn0ZqrWaNyEc66uw1jIS7RbE4palGjGJa-PYfSLNb8iJ85MGV_fv2fk-uLzj_5rvb768q3_tK5tA3yunRAwUlCdaByqoRnawQzABaOtEZQZB9Y6IQeKFDmXSmGjOsRxlCicg4GfkY_H3Nv9sMPRltmTmfRt8juTfulovP5bCX6rN_FOc9VyoWQJeH8fkOLPPeZZ73y2WG4SMO6zppxx1nSy4E-jVHZCKskK-u4f9CbuUyiXWKhWSVqWLhQ9UjbFnBO6h7kp6KVzfexcl8710rk-FM_bxws_OP6UXAB2BHKRwgbTo6__m_obLoC5NQ</recordid><startdate>20130301</startdate><enddate>20130301</enddate><creator>Alavi, S. 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Hamed</au><au>Ruiz, Victor</au><au>Krasieva, Tatiana</au><au>Botvinick, Elliot L.</au><au>Kheradvar, Arash</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Characterizing the Collagen Fiber Orientation in Pericardial Leaflets Under Mechanical Loading Conditions</atitle><jtitle>Annals of biomedical engineering</jtitle><stitle>Ann Biomed Eng</stitle><addtitle>Ann Biomed Eng</addtitle><date>2013-03-01</date><risdate>2013</risdate><volume>41</volume><issue>3</issue><spage>547</spage><epage>561</epage><pages>547-561</pages><issn>0090-6964</issn><eissn>1573-9686</eissn><abstract>When implanted inside the body, bioprosthetic heart valve leaflets experience a variety of cyclic mechanical stresses such as shear stress due to blood flow when the valve is open, flexural stress due to cyclic opening and closure of the valve, and tensile stress when the valve is closed. These types of stress lead to a variety of failure modes. In either a natural valve leaflet or a processed pericardial tissue leaflet, collagen fibers reinforce the tissue and provide structural integrity such that the very thin leaflet can stand enormous loads related to cyclic pressure changes. The mechanical response of the leaflet tissue greatly depends on collagen fiber concentration, characteristics, and orientation. Thus, understating the microstructure of pericardial tissue and its response to dynamic loading is crucial for the development of more durable heart valve, and computational models to predict heart valves' behavior. In this work, we have characterized the 3D collagen fiber arrangement of bovine pericardial tissue leaflets in response to a variety of different loading conditions under Second-Harmonic Generation Microscopy. This real-time visualization method assists in better understanding of the effect of cyclic load on collagen fiber orientation in time and space.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>23180029</pmid><doi>10.1007/s10439-012-0696-z</doi><tpages>15</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Biochemistry Biological and Medical Physics Biomechanical Phenomena Biomedical and Life Sciences Biomedical Engineering - instrumentation Biomedical Engineering and Bioengineering Biomedicine Biophysics Bioprosthesis Cattle Classical Mechanics Collagen - chemistry Collagen - physiology Equipment Failure Analysis - instrumentation Fibers Heart Valve Prosthesis Humans Models, Cardiovascular Pericardium - chemistry Pericardium - physiology Shear stress Stress, Mechanical Tensile stress Tissues |
| title | Characterizing the Collagen Fiber Orientation in Pericardial Leaflets Under Mechanical Loading Conditions |
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