T cells and their eons-old obsession with MHC

Summary T cells bearing receptors made up of α and β chains (TCRs) usually react with peptides bound to major histocompatibility complex proteins (MHC). This bias could be imposed by positive selection, the phenomenon that selects thymocytes to mature into T cells only if the TCRs they bear react wi...

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Veröffentlicht in:	Immunological reviews 2012-11, Vol.250 (1), p.49-60
Hauptverfasser:	Yin, Lei, Scott-Browne, James, Kappler, John W., Gapin, Laurent, Marrack, Philippa
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens - chemistry Antigens - immunology Antigens - metabolism Binding Sites comparative immunology Cross Reactions Humans Major Histocompatibility Complex - immunology Mice Models, Molecular Peptides - chemistry Peptides - immunology Peptides - metabolism Protein Binding Protein Conformation Receptors, Antigen, T-Cell, alpha-beta - chemistry Receptors, Antigen, T-Cell, alpha-beta - immunology Receptors, Antigen, T-Cell, alpha-beta - metabolism T cells T-cell receptors T-Lymphocytes - cytology T-Lymphocytes - immunology T-Lymphocytes - metabolism Thymocytes - cytology Thymocytes - immunology thymus Thymus Gland
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