Bcl‐2 level as a biomarker for 13q14 deletion in CLL

Background Deletion 13q14.3 is the most common cytogenetic abnormality in chronic lymphocytic leukemia (CLL). Previously it was reported that miR‐15/16 is the target of 13q14 deletions and plays a tumor suppressor role by suppressing Bcl‐2. Therefore, Bcl‐2 expression was examined more closely to de...

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Veröffentlicht in:	Cytometry. Part B, Clinical cytometry Clinical cytometry, 2013-07, Vol.84B (4), p.237-247
Hauptverfasser:	Degheidy, Heba A., Gadalla, Shahinaz M., Farooqui, Mohammed Z. H., Abbasi, Fatima, Arthur, Diane C., Bauer, Steven R., Wilson, Wyndham H., Wiestner, Adrian, Stetler‐Stevenson, M. A., Marti, Gerald E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Animals Bcl‐2 Chromosome Aberrations Chromosomes, Human, Pair 13 chronic lymphocytic leukemia del 13q14 Female flow cytometry Flow Cytometry - methods Gene Expression Regulation, Neoplastic Genes, bcl-2 - genetics hemizygous/homozygous deletion Humans Leukemia, Lymphocytic, Chronic, B-Cell - diagnosis Leukemia, Lymphocytic, Chronic, B-Cell - genetics Leukemia, Lymphocytic, Chronic, B-Cell - pathology Male Middle Aged Prognosis Sequence Deletion
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