Protective MCMV immunity by vaccination of the salivary gland via Wharton's duct: replication‐deficient recombinant adenovirus expressing individual MCMV genes elicits protection similar to that of MCMV

Salivary glands, a major component of the mucosal immune system, confer antigen‐specific immunity to mucosally acquired pathogens. We investigated whether a physiological route of inoculation and a subunit vaccine approach elicited MCMV‐specific and protective immunity. Mice were inoculated by retro...

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Veröffentlicht in:	The FASEB journal 2014-04, Vol.28 (4), p.1698-1710
Hauptverfasser:	Liu, Guangliang, Zhang, Fangfang, Wang, Ruixue, London, Lucille, London, Steven D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - genetics Animals Antibodies, Viral - blood Antibodies, Viral - immunology DNA, Recombinant Female Fluorescent Antibody Technique Gene Expression - immunology Germinal Center - immunology Germinal Center - metabolism Herpesviridae Infections - immunology Herpesviridae Infections - prevention & control Herpesviridae Infections - virology Humans Immediate-Early Proteins - genetics Immediate-Early Proteins - immunology Immediate-Early Proteins - metabolism Immunity - immunology inflammation Mice Mice, Inbred BALB C mucosal immunity Muromegalovirus - genetics Muromegalovirus - immunology Muromegalovirus - metabolism PAX5 Transcription Factor - genetics PAX5 Transcription Factor - immunology PAX5 Transcription Factor - metabolism Research Communications Reverse Transcriptase Polymerase Chain Reaction Salivary Ducts - immunology Salivary Ducts - metabolism Salivary Glands - immunology Salivary Glands - metabolism T-Lymphocytes - immunology T-Lymphocytes - metabolism Vaccination - methods vaccine development Viral Proteins - genetics Viral Proteins - immunology Viral Proteins - metabolism Viral Vaccines - administration & dosage Viral Vaccines - immunology Virus Replication - genetics
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