Sox2 modulates Lef-1 expression during airway submucosal gland development

Tracheobronchial submucosal glands (SMGs) are derived from one or more multipotent glandular stem cells that coalesce to form a placode in surface airway epithelium (SAE). Wnt/β-catenin-dependent induction of lymphoid enhancer factor (Lef-1) gene expression during placode formation is an early event...

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Veröffentlicht in:	American journal of physiology. Lung cellular and molecular physiology 2014-04, Vol.306 (7), p.L645-L660
Hauptverfasser:	Xie, Weiliang, Lynch, Thomas J, Liu, Xiaoming, Tyler, Scott R, Yu, Shuyang, Zhou, Xinyuan, Luo, Meihui, Kusner, David M, Sun, Xingshen, Yi, Yaling, Zhang, Yulong, Goodheart, Michael J, Parekh, Kalpaj R, Wells, James M, Xue, Hai-Hui, Pevny, Larysa H, Engelhardt, John F
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Lung Injury - physiopathology Animals Animals, Newborn beta Catenin - physiology Binding sites Deoxyribonucleic acid DNA Gene expression Humans Lymphoid Enhancer-Binding Factor 1 - biosynthesis Mice Mice, Transgenic Promoter Regions, Genetic - physiology Proteins Respiratory System - growth & development SOXB1 Transcription Factors - physiology Stem cells Wnt Proteins - physiology
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