Retinal waves coordinate patterned activity throughout the developing visual system

The morphological and functional development of the vertebrate nervous system is initially governed by genetic factors and subsequently refined by neuronal activity. However, fundamental features of the nervous system emerge before sensory experience is possible. Thus, activity-dependent development...

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Veröffentlicht in:	Nature (London) 2012-10, Vol.490 (7419), p.219-225
Hauptverfasser:	Ackman, James B., Burbridge, Timothy J., Crair, Michael C.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/136 631/378/2613 631/378/548 Animals Animals, Newborn Biological and medical sciences Brain stimulation Bridged Bicyclo Compounds, Heterocyclic - pharmacology Calcium - metabolism Eye and associated structures. Visual pathways and centers. Vision Eyes & eyesight Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Developmental - drug effects Genetic factors Humanities and Social Sciences Methods Mice Mice, Inbred C57BL multidisciplinary Neurons Nicotinic Agonists - pharmacology Physiological aspects Psychological aspects Pyridines - pharmacology Retina - drug effects Retina - growth & development Retinal ganglion cells Retinal Neurons - cytology Retinal Neurons - drug effects Science Vertebrates: nervous system and sense organs Visual Cortex - cytology Visual Cortex - drug effects Visual Cortex - growth & development Visual learning
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