BxPC3 pancreatic cancer cells express a truncated Smad4 protein upon PI3K and mTOR inhibition

Smad4 is a critical regulator of transforming growth factor (TGF)-β signaling and is defective in numerous human cancers. In total, 30% of pancreatic cancers harbor a homozygous deletion of Smad4. The human pancreatic cancer cell line, BxPC3, has been reported to be Smad4-null due to a homozygous de...

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Veröffentlicht in:	Oncology letters 2014-04, Vol.7 (4), p.1165-1168
Hauptverfasser:	LEGENDRE, ONICA, SOOKDEO, AYISHA, FOSTER, DAVID A
Format:	Artikel
Sprache:	eng
Schlagworte:	Biotechnology BxPC3 cells Cancer Cancer cells chromosomal instability Chromosomes Deoxyribonucleic acid DNA DNA polymerase Genes Kinases Medical prognosis Oncology Oncology, Experimental Pancreatic cancer Physiological aspects Proteins Smad4 Studies transforming growth factor-β Transforming growth factors
Online-Zugang:	Volltext
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