The Role of Oxidative Stress in the Development of Cisplatin Resistance in Epithelial Ovarian Cancer

Objective: To investigate the role of oxidative stress in the development of cisplatin resistance in epithelial ovarian cancer (EOC). Methods: Two parent EOC cell lines (MDAH-2774 and SKOV-3) and their chemoresistant counterparts (cisplatin, 50 µmol/L) were used. Total RNA was extracted and subjecte...

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Veröffentlicht in:	Reproductive sciences (Thousand Oaks, Calif.) Calif.), 2014-04, Vol.21 (4), p.503-508
Hauptverfasser:	Belotte, Jimmy, Fletcher, Nicole M., Awonuga, Awoniyi O., Alexis, Mitchell, Abu-Soud, Husam M., Saed, Mohammed G., Diamond, Michael P., Saed, Ghassan M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - pharmacology Carcinoma, Ovarian Epithelial Cell Line, Tumor Cell Proliferation - drug effects Cisplatin - pharmacology Drug Resistance, Neoplasm Embryology Female Gene Expression Regulation, Enzymologic Gene Expression Regulation, Neoplastic Glutathione Reductase - genetics Glutathione Reductase - metabolism Humans Medicine & Public Health Neoplasms, Glandular and Epithelial - genetics Neoplasms, Glandular and Epithelial - metabolism Neoplasms, Glandular and Epithelial - pathology Nitrates - metabolism Nitric Oxide Synthase Type II - genetics Nitric Oxide Synthase Type II - metabolism Nitrites - metabolism Obstetrics/Perinatology/Midwifery Original Original Article Ovarian Neoplasms - genetics Ovarian Neoplasms - metabolism Ovarian Neoplasms - pathology Oxidative Stress - drug effects Reproductive Medicine RNA, Messenger - metabolism
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