Cell biological steps and checkpoints in accessing NK cell cytotoxicity

Natural killer (NK) cell‐mediated cytotoxicity is governed by the formation of a lytic immune synapse in discrete regulated steps, which give rise to an extensive array of cellular checkpoints in accessing NK cell‐mediated cytolytic defense. Appropriate progression through these cell biological step...

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Veröffentlicht in:	Immunology and cell biology 2014-03, Vol.92 (3), p.245-255
Hauptverfasser:	Mace, Emily M, Dongre, Prachi, Hsu, Hsiang‐Ting, Sinha, Papiya, James, Ashley M, Mann, Shaina S, Forbes, Lisa R, Watkin, Levi B, Orange, Jordan S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Cycle Checkpoints cytotoxicity Cytotoxicity, Immunologic Humans Immunological Synapses - immunology innate immunity Killer Cells, Natural - cytology Killer Cells, Natural - immunology natural killer cell Review
Online-Zugang:	Volltext
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