Role of the Vasa Vasorum and Vascular Resident Stem Cells in Atherosclerosis
Atherosclerosis is considered an “inside-out” response, that begins with the dysfunction of intimal endothelial cells and leads to neointimal plaque formation. The adventitia of large blood vessels has been recognized as an active part of the vessel wall that is involved in the process of atheroscle...
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| description | Atherosclerosis is considered an “inside-out” response, that begins with the dysfunction of intimal endothelial cells and leads to neointimal plaque formation. The adventitia of large blood vessels has been recognized as an active part of the vessel wall that is involved in the process of atherosclerosis. There are characteristic changes in the adventitial vasa vasorum that are associated with the development of atheromatous plaques. However, whether vasa vasorum plays a causative or merely reactive role in the atherosclerotic process is not completely clear. Recent studies report that the vascular wall contains a number of stem/progenitor cells that may contribute to vascular remodeling. Microvessels serve as the vascular niche that maintains the resident stem/progenitor cells of the tissue. Therefore, the vasa vasorum may contribute to vascular remodeling through not only its conventional function as a blood conducting tube, but also its new conceptual function as a stem cell reservoir. This brief review highlights the recent advances contributing to our understanding of the role of the adventitial vasa vasorum in the atherosclerosis and discusses new concept that involves vascular-resident factors, the vasa vasorum and its associated vascular-resident stem cells, in the atherosclerotic process. |
| doi_str_mv | 10.1155/2014/701571 |
| format | Article |
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The adventitia of large blood vessels has been recognized as an active part of the vessel wall that is involved in the process of atherosclerosis. There are characteristic changes in the adventitial vasa vasorum that are associated with the development of atheromatous plaques. However, whether vasa vasorum plays a causative or merely reactive role in the atherosclerotic process is not completely clear. Recent studies report that the vascular wall contains a number of stem/progenitor cells that may contribute to vascular remodeling. Microvessels serve as the vascular niche that maintains the resident stem/progenitor cells of the tissue. Therefore, the vasa vasorum may contribute to vascular remodeling through not only its conventional function as a blood conducting tube, but also its new conceptual function as a stem cell reservoir. This brief review highlights the recent advances contributing to our understanding of the role of the adventitial vasa vasorum in the atherosclerosis and discusses new concept that involves vascular-resident factors, the vasa vasorum and its associated vascular-resident stem cells, in the atherosclerotic process.</description><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2014/701571</identifier><identifier>PMID: 24724094</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Puplishing Corporation</publisher><subject>Adventitia - metabolism ; Adventitia - pathology ; Angiogenesis ; Animals ; Atherosclerosis ; Atherosclerosis - metabolism ; Atherosclerosis - pathology ; Humans ; Muscular system ; Oxidative stress ; Pathogenesis ; Plaque, Atherosclerotic - metabolism ; Plaque, Atherosclerotic - pathology ; Review ; Smooth muscle ; Stem cells ; Stem Cells - metabolism ; Stem Cells - pathology ; Studies ; Vasa Vasorum - metabolism ; Vasa Vasorum - pathology ; Vascular Remodeling ; Veins & arteries</subject><ispartof>BioMed research international, 2014-01, Vol.2014 (2014), p.1-8</ispartof><rights>Copyright © 2014 Jun-ichi Kawabe and Naoyuki Hasebe.</rights><rights>Copyright © 2014 Jun-ichi Kawabe and Naoyuki Hasebe. Jun-ichi Kawabe et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2014 J.-i. Kawabe and N. Hasebe. 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c532t-aa5a98481389ee12c64d018e03e305977d2a93223b35d3004d1f86ea27927db33</citedby><cites>FETCH-LOGICAL-c532t-aa5a98481389ee12c64d018e03e305977d2a93223b35d3004d1f86ea27927db33</cites><orcidid>0000-0002-4837-6598</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3960518/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3960518/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24724094$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Aikawa, Masanori</contributor><creatorcontrib>Kawabe, Jun-ichi</creatorcontrib><creatorcontrib>Hasebe, Naoyuki</creatorcontrib><title>Role of the Vasa Vasorum and Vascular Resident Stem Cells in Atherosclerosis</title><title>BioMed research international</title><addtitle>Biomed Res Int</addtitle><description>Atherosclerosis is considered an “inside-out” response, that begins with the dysfunction of intimal endothelial cells and leads to neointimal plaque formation. The adventitia of large blood vessels has been recognized as an active part of the vessel wall that is involved in the process of atherosclerosis. There are characteristic changes in the adventitial vasa vasorum that are associated with the development of atheromatous plaques. However, whether vasa vasorum plays a causative or merely reactive role in the atherosclerotic process is not completely clear. Recent studies report that the vascular wall contains a number of stem/progenitor cells that may contribute to vascular remodeling. Microvessels serve as the vascular niche that maintains the resident stem/progenitor cells of the tissue. Therefore, the vasa vasorum may contribute to vascular remodeling through not only its conventional function as a blood conducting tube, but also its new conceptual function as a stem cell reservoir. This brief review highlights the recent advances contributing to our understanding of the role of the adventitial vasa vasorum in the atherosclerosis and discusses new concept that involves vascular-resident factors, the vasa vasorum and its associated vascular-resident stem cells, in the atherosclerotic process.</description><subject>Adventitia - metabolism</subject><subject>Adventitia - pathology</subject><subject>Angiogenesis</subject><subject>Animals</subject><subject>Atherosclerosis</subject><subject>Atherosclerosis - metabolism</subject><subject>Atherosclerosis - pathology</subject><subject>Humans</subject><subject>Muscular system</subject><subject>Oxidative stress</subject><subject>Pathogenesis</subject><subject>Plaque, Atherosclerotic - metabolism</subject><subject>Plaque, Atherosclerotic - pathology</subject><subject>Review</subject><subject>Smooth muscle</subject><subject>Stem cells</subject><subject>Stem Cells - metabolism</subject><subject>Stem Cells - pathology</subject><subject>Studies</subject><subject>Vasa Vasorum - metabolism</subject><subject>Vasa Vasorum - pathology</subject><subject>Vascular Remodeling</subject><subject>Veins & arteries</subject><issn>2314-6133</issn><issn>2314-6141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkctr3DAQxkVJaUKaU84pglxKyzYaPSzrEghLX7BQSB9XobXGXQXbSiS7pf99ZZwsaS7VYTSgnz6-mY-QU2DvAJS64AzkhWagNDwjR1yAXFUg4WDfC3FITnK-YeXUUDFTvSCHXGoumZFHZHMdO6SxpeMO6Q-X3VximnrqBj_3zdS5RK8xB4_DSL-O2NM1dl2mYaBX5VeKuenmGvJL8rx1XcaT-_uYfP_w_tv602rz5ePn9dVm1SjBx5Vzypla1iBqgwi8qaRnUCMTKJgyWnvujOBcbIXygjHpoa0rdFwbrv1WiGNyuejeTtsefVOMJdfZ2xR6l_7Y6IL992UIO_sz_rLCVExBXQRe3wukeDdhHm0fclOmcgPGKVtQvAKuWa0Lev4EvYlTGsp4hQIQsgwyO3q7UE1ZRE7Y7s0As3NQdg7KLkEV-tVj_3v2IZYCvFmAXRi8-x3-o3a2wFgQbN0elgYqocVfcYSh_A</recordid><startdate>20140101</startdate><enddate>20140101</enddate><creator>Kawabe, Jun-ichi</creator><creator>Hasebe, Naoyuki</creator><general>Hindawi Puplishing Corporation</general><general>Hindawi Publishing Corporation</general><general>Hindawi Limited</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QO</scope><scope>7T7</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>CWDGH</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-4837-6598</orcidid></search><sort><creationdate>20140101</creationdate><title>Role of the Vasa Vasorum and Vascular Resident Stem Cells in Atherosclerosis</title><author>Kawabe, Jun-ichi ; Hasebe, Naoyuki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c532t-aa5a98481389ee12c64d018e03e305977d2a93223b35d3004d1f86ea27927db33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adventitia - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BioMed research international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kawabe, Jun-ichi</au><au>Hasebe, Naoyuki</au><au>Aikawa, Masanori</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of the Vasa Vasorum and Vascular Resident Stem Cells in Atherosclerosis</atitle><jtitle>BioMed research international</jtitle><addtitle>Biomed Res Int</addtitle><date>2014-01-01</date><risdate>2014</risdate><volume>2014</volume><issue>2014</issue><spage>1</spage><epage>8</epage><pages>1-8</pages><issn>2314-6133</issn><eissn>2314-6141</eissn><abstract>Atherosclerosis is considered an “inside-out” response, that begins with the dysfunction of intimal endothelial cells and leads to neointimal plaque formation. The adventitia of large blood vessels has been recognized as an active part of the vessel wall that is involved in the process of atherosclerosis. There are characteristic changes in the adventitial vasa vasorum that are associated with the development of atheromatous plaques. However, whether vasa vasorum plays a causative or merely reactive role in the atherosclerotic process is not completely clear. Recent studies report that the vascular wall contains a number of stem/progenitor cells that may contribute to vascular remodeling. Microvessels serve as the vascular niche that maintains the resident stem/progenitor cells of the tissue. Therefore, the vasa vasorum may contribute to vascular remodeling through not only its conventional function as a blood conducting tube, but also its new conceptual function as a stem cell reservoir. This brief review highlights the recent advances contributing to our understanding of the role of the adventitial vasa vasorum in the atherosclerosis and discusses new concept that involves vascular-resident factors, the vasa vasorum and its associated vascular-resident stem cells, in the atherosclerotic process.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Puplishing Corporation</pub><pmid>24724094</pmid><doi>10.1155/2014/701571</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-4837-6598</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adventitia - metabolism Adventitia - pathology Angiogenesis Animals Atherosclerosis Atherosclerosis - metabolism Atherosclerosis - pathology Humans Muscular system Oxidative stress Pathogenesis Plaque, Atherosclerotic - metabolism Plaque, Atherosclerotic - pathology Review Smooth muscle Stem cells Stem Cells - metabolism Stem Cells - pathology Studies Vasa Vasorum - metabolism Vasa Vasorum - pathology Vascular Remodeling Veins & arteries |
| title | Role of the Vasa Vasorum and Vascular Resident Stem Cells in Atherosclerosis |
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