mTOR pathway in colorectal cancer: an update

The mammalian target of rapamycin (mTOR) has emerged as a potential target for drug development, particularly due to the fact that it plays such a crucial role in cancer biology. In addition, next-generation mTOR inhibitors have become available, marking an exciting new phase in mTOR-based therapy....

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Veröffentlicht in:	Oncotarget 2014-01, Vol.5 (1), p.49-66
Hauptverfasser:	Francipane, Maria Giovanna, Lagasse, Eric
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Colorectal Neoplasms - drug therapy Colorectal Neoplasms - genetics Colorectal Neoplasms - metabolism Humans Molecular Targeted Therapy Precision Medicine Review Signal Transduction TOR Serine-Threonine Kinases - antagonists & inhibitors TOR Serine-Threonine Kinases - genetics TOR Serine-Threonine Kinases - metabolism
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