Role of non-acid reflux in patients with non-erosive reflux disease

Role of non-acid reflux in patients with non-erosive reflux disease

Non-erosive reflux disease (NERD) is the most common presentation of gastroesophageal reflux disease. Although acid reflux is the most important cause of symptom generation in NERD patients, non-acid reflux is also associated with reflux symptoms. The temporal relation between symptoms and reflux ep...

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Veröffentlicht in:Annals of gastroenterology 2013-01, Vol.26 (2), p.100-103
Hauptverfasser: Karamanolis, Georgios P, Tutuian, Radu
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Invited Review
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Tutuian, Radu
description Non-erosive reflux disease (NERD) is the most common presentation of gastroesophageal reflux disease. Although acid reflux is the most important cause of symptom generation in NERD patients, non-acid reflux is also associated with reflux symptoms. The temporal relation between symptoms and reflux episodes is of importance in evaluating the results of combined pH-impedance monitoring in NERD patients. Mucosal hypersensitivity and mechanical stimulation due to great volume of non-acid reflux are among the putative mechanisms of symptom generation.
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title Role of non-acid reflux in patients with non-erosive reflux disease
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