Effect of cold ischemia/reperfusion injury and/or shear stress with portal hypertension on the expression of matrix metalloproteinase-9
Matrix metalloproteinase (MMP)-9 plays an important role in liver regeneration after liver surgery. MMP-9 behavior is complicated in cold ischemia/warm reperfusion injury (CIWRI) and/or shear stress with portal hypertension. Small-for-size grafts (SFSGs) are also an issue. We used a rat model to exa...
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| Veröffentlicht in: | Annals of gastroenterology 2012, Vol.25 (4), p.345-351 |
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| creator | Hori, Tomohide Uemoto, Shinji Chen, Feng Ann-Baine, Marie T Gardner, Lindsay B Hata, Toshiyuki Kuribayashi, Kagemasa Kato, Takuma Saito, Kanako Wang, Linan Torii, Mie Endo, Kosuke Jobara, Kanta Sulistiono, Beni Nguyen, Justin H |
| description | Matrix metalloproteinase (MMP)-9 plays an important role in liver regeneration after liver surgery. MMP-9 behavior is complicated in cold ischemia/warm reperfusion injury (CIWRI) and/or shear stress with portal hypertension. Small-for-size grafts (SFSGs) are also an issue.
We used a rat model to examine MMP-9 expression 6 h after laparotomy, a temporal clamp (Pringle maneuver), orthotopic liver transplantation (OLT) with a whole-liver graft (100% OLT), partial hepatectomy without the Pringle maneuver (60% hepatectomy) and split orthotopic liver transplantation (SOLT) with a SFSG (40% SOLT) were investigated. Four liver samples were collected in each group.
The normalized ratio of MMP-9 was not significantly different with a temporal clamp (P = 0.1963), 100% OLT (P = 0.1781) and 60% hepatectomy (P = 0.2367), but it was significantly higher with 40% SOLT compared to that with laparotomy (P = 0.0159).
Forty percent SOLT is accompanied by not only CIWRI but also shear stress. This fatal damage results in increased MMP-9 expression. |
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We used a rat model to examine MMP-9 expression 6 h after laparotomy, a temporal clamp (Pringle maneuver), orthotopic liver transplantation (OLT) with a whole-liver graft (100% OLT), partial hepatectomy without the Pringle maneuver (60% hepatectomy) and split orthotopic liver transplantation (SOLT) with a SFSG (40% SOLT) were investigated. Four liver samples were collected in each group.
The normalized ratio of MMP-9 was not significantly different with a temporal clamp (P = 0.1963), 100% OLT (P = 0.1781) and 60% hepatectomy (P = 0.2367), but it was significantly higher with 40% SOLT compared to that with laparotomy (P = 0.0159).
Forty percent SOLT is accompanied by not only CIWRI but also shear stress. This fatal damage results in increased MMP-9 expression.</description><identifier>ISSN: 1108-7471</identifier><identifier>EISSN: 1792-7463</identifier><identifier>PMID: 24714252</identifier><language>eng</language><publisher>Greece: Hellenic Society of Gastroenterology</publisher><subject>Original</subject><ispartof>Annals of gastroenterology, 2012, Vol.25 (4), p.345-351</ispartof><rights>Copyright: © Hellenic Society of Gastroenterology 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3959407/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3959407/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,4023,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24714252$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hori, Tomohide</creatorcontrib><creatorcontrib>Uemoto, Shinji</creatorcontrib><creatorcontrib>Chen, Feng</creatorcontrib><creatorcontrib>Ann-Baine, Marie T</creatorcontrib><creatorcontrib>Gardner, Lindsay B</creatorcontrib><creatorcontrib>Hata, Toshiyuki</creatorcontrib><creatorcontrib>Kuribayashi, Kagemasa</creatorcontrib><creatorcontrib>Kato, Takuma</creatorcontrib><creatorcontrib>Saito, Kanako</creatorcontrib><creatorcontrib>Wang, Linan</creatorcontrib><creatorcontrib>Torii, Mie</creatorcontrib><creatorcontrib>Endo, Kosuke</creatorcontrib><creatorcontrib>Jobara, Kanta</creatorcontrib><creatorcontrib>Sulistiono, Beni</creatorcontrib><creatorcontrib>Nguyen, Justin H</creatorcontrib><title>Effect of cold ischemia/reperfusion injury and/or shear stress with portal hypertension on the expression of matrix metalloproteinase-9</title><title>Annals of gastroenterology</title><addtitle>Ann Gastroenterol</addtitle><description>Matrix metalloproteinase (MMP)-9 plays an important role in liver regeneration after liver surgery. MMP-9 behavior is complicated in cold ischemia/warm reperfusion injury (CIWRI) and/or shear stress with portal hypertension. Small-for-size grafts (SFSGs) are also an issue.
We used a rat model to examine MMP-9 expression 6 h after laparotomy, a temporal clamp (Pringle maneuver), orthotopic liver transplantation (OLT) with a whole-liver graft (100% OLT), partial hepatectomy without the Pringle maneuver (60% hepatectomy) and split orthotopic liver transplantation (SOLT) with a SFSG (40% SOLT) were investigated. Four liver samples were collected in each group.
The normalized ratio of MMP-9 was not significantly different with a temporal clamp (P = 0.1963), 100% OLT (P = 0.1781) and 60% hepatectomy (P = 0.2367), but it was significantly higher with 40% SOLT compared to that with laparotomy (P = 0.0159).
Forty percent SOLT is accompanied by not only CIWRI but also shear stress. This fatal damage results in increased MMP-9 expression.</description><subject>Original</subject><issn>1108-7471</issn><issn>1792-7463</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><recordid>eNpVUN1KwzAULqK4OX0FyaU3ZU3SJu2NIGP-wMAbvS5Zc2Iz2qQmqW5P4Gsb5xSFwzmHc74f-I6SKeYVSXnO6HHccVbGneNJcub9JssKxvP8NJmQeMtJQabJx1IpaAKyCjW2k0j7poVei7mDAZwavbYGabMZ3Q4JI-fWId-CiD048B6969CiwbogOtTuIiWA2XNihRYQbIcv3P6iUC-C01vUQ4R3dnA2gDbCQ1qdJydKdB4uDnOWPN8unxb36erx7mFxs0oHwlhIcYWBlhlngmAs15goAZQ3FDeVJAxjTpoSKCgpGcGcrSUrRUWVKAvIqcwKOkuuv3WHcd2DbMAEJ7p6cLoXbldboev_H6Pb-sW-1bQqqjzjUeDqIODs6wg-1H3MDLpOGLCjr3FJWERyQiP08q_Xr8lP-vQTvD-Ghg</recordid><startdate>2012</startdate><enddate>2012</enddate><creator>Hori, Tomohide</creator><creator>Uemoto, Shinji</creator><creator>Chen, Feng</creator><creator>Ann-Baine, Marie T</creator><creator>Gardner, Lindsay B</creator><creator>Hata, Toshiyuki</creator><creator>Kuribayashi, Kagemasa</creator><creator>Kato, Takuma</creator><creator>Saito, Kanako</creator><creator>Wang, Linan</creator><creator>Torii, Mie</creator><creator>Endo, Kosuke</creator><creator>Jobara, Kanta</creator><creator>Sulistiono, Beni</creator><creator>Nguyen, Justin H</creator><general>Hellenic Society of Gastroenterology</general><scope>NPM</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>2012</creationdate><title>Effect of cold ischemia/reperfusion injury and/or shear stress with portal hypertension on the expression of matrix metalloproteinase-9</title><author>Hori, Tomohide ; Uemoto, Shinji ; Chen, Feng ; Ann-Baine, Marie T ; Gardner, Lindsay B ; Hata, Toshiyuki ; Kuribayashi, Kagemasa ; Kato, Takuma ; Saito, Kanako ; Wang, Linan ; Torii, Mie ; Endo, Kosuke ; Jobara, Kanta ; Sulistiono, Beni ; Nguyen, Justin H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p266t-191e38076a211db12fae37c31c9d261172c8e3efdd62176bd68a93fa85e43d053</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Original</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hori, Tomohide</creatorcontrib><creatorcontrib>Uemoto, Shinji</creatorcontrib><creatorcontrib>Chen, Feng</creatorcontrib><creatorcontrib>Ann-Baine, Marie T</creatorcontrib><creatorcontrib>Gardner, Lindsay B</creatorcontrib><creatorcontrib>Hata, Toshiyuki</creatorcontrib><creatorcontrib>Kuribayashi, Kagemasa</creatorcontrib><creatorcontrib>Kato, Takuma</creatorcontrib><creatorcontrib>Saito, Kanako</creatorcontrib><creatorcontrib>Wang, Linan</creatorcontrib><creatorcontrib>Torii, Mie</creatorcontrib><creatorcontrib>Endo, Kosuke</creatorcontrib><creatorcontrib>Jobara, Kanta</creatorcontrib><creatorcontrib>Sulistiono, Beni</creatorcontrib><creatorcontrib>Nguyen, Justin H</creatorcontrib><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Annals of gastroenterology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hori, Tomohide</au><au>Uemoto, Shinji</au><au>Chen, Feng</au><au>Ann-Baine, Marie T</au><au>Gardner, Lindsay B</au><au>Hata, Toshiyuki</au><au>Kuribayashi, Kagemasa</au><au>Kato, Takuma</au><au>Saito, Kanako</au><au>Wang, Linan</au><au>Torii, Mie</au><au>Endo, Kosuke</au><au>Jobara, Kanta</au><au>Sulistiono, Beni</au><au>Nguyen, Justin H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of cold ischemia/reperfusion injury and/or shear stress with portal hypertension on the expression of matrix metalloproteinase-9</atitle><jtitle>Annals of gastroenterology</jtitle><addtitle>Ann Gastroenterol</addtitle><date>2012</date><risdate>2012</risdate><volume>25</volume><issue>4</issue><spage>345</spage><epage>351</epage><pages>345-351</pages><issn>1108-7471</issn><eissn>1792-7463</eissn><abstract>Matrix metalloproteinase (MMP)-9 plays an important role in liver regeneration after liver surgery. MMP-9 behavior is complicated in cold ischemia/warm reperfusion injury (CIWRI) and/or shear stress with portal hypertension. Small-for-size grafts (SFSGs) are also an issue.
We used a rat model to examine MMP-9 expression 6 h after laparotomy, a temporal clamp (Pringle maneuver), orthotopic liver transplantation (OLT) with a whole-liver graft (100% OLT), partial hepatectomy without the Pringle maneuver (60% hepatectomy) and split orthotopic liver transplantation (SOLT) with a SFSG (40% SOLT) were investigated. Four liver samples were collected in each group.
The normalized ratio of MMP-9 was not significantly different with a temporal clamp (P = 0.1963), 100% OLT (P = 0.1781) and 60% hepatectomy (P = 0.2367), but it was significantly higher with 40% SOLT compared to that with laparotomy (P = 0.0159).
Forty percent SOLT is accompanied by not only CIWRI but also shear stress. This fatal damage results in increased MMP-9 expression.</abstract><cop>Greece</cop><pub>Hellenic Society of Gastroenterology</pub><pmid>24714252</pmid><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| title | Effect of cold ischemia/reperfusion injury and/or shear stress with portal hypertension on the expression of matrix metalloproteinase-9 |
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