The C-Terminal Region of Human Angiogenin has a Dual Role in Enzymatic Activity

The ribonucleolytic activity of angiogenin (Ang) is essential to Ang's capacity to induce blood vessel formation. Previous x-ray diffraction and mutagenesis results have shown that the active site of the human protein is obstructed by Gln-117 and imply that the C-terminal region of Ang must und...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1996-04, Vol.93 (8), p.3243-3247
Hauptverfasser:	Russo, Nello, Nobile, Valentina, Di Donato, Alberto, Riordan, James F., Vallee, Bert L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Active sites Amino Acid Sequence Amino acids Angiogenesis Inducing Agents - chemistry Angiogenesis Inducing Agents - genetics Angiogenesis Inducing Agents - metabolism Binding sites Binding Sites - genetics Biochemistry Blood vessels Enzymes Escherichia coli - genetics Humans In Vitro Techniques Kinetics Methanol - pharmacology Models, Molecular Molecular Sequence Data Molecular Structure Mutagenesis, Site-Directed Protein Conformation Protein Folding Proteins Proteins - chemistry Proteins - genetics Proteins - metabolism Pyrimidines Recombinant Proteins - chemistry Recombinant Proteins - genetics Recombinant Proteins - metabolism Ribonuclease, Pancreatic - chemistry Ribonuclease, Pancreatic - genetics Ribonuclease, Pancreatic - metabolism RNA Sequence Homology, Amino Acid Site directed mutagenesis Transfer RNA
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