The role of the neurokinin-1 receptor in stress-induced reinstatement of alcohol and cocaine seeking

Neurokinin-1 receptors (NK1Rs) have been shown to mediate alcohol and opiate, but not cocaine reward in rodents. We recently reported that NK1R antagonism also blocks stress-induced reinstatement of alcohol seeking in rats, but it is presently unknown whether these antirelapse properties extend to o...

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Veröffentlicht in:	Neuropsychopharmacology (New York, N.Y.) N.Y.), 2014-04, Vol.39 (5), p.1093-1101
Hauptverfasser:	Schank, Jesse R, King, Courtney E, Sun, Hui, Cheng, Kejun, Rice, Kenner C, Heilig, Markus, Weinshenker, David, Schroeder, Jason P
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic alpha-2 Receptor Antagonists - pharmacology Alcohol-Related Disorders - drug therapy Alcohol-Related Disorders - etiology Alcohol-Related Disorders - metabolism Alcoholism Animals Behavior, Addictive - chemically induced Behavior, Addictive - drug therapy Behavior, Addictive - etiology Behavior, Addictive - metabolism Brain Brain - metabolism Central Nervous System Depressants - administration & dosage Central Nervous System Depressants - pharmacology Cocaine Cocaine - administration & dosage Cocaine - pharmacology Cocaine-Related Disorders - drug therapy Cocaine-Related Disorders - etiology Cocaine-Related Disorders - metabolism Dopamine Uptake Inhibitors - administration & dosage Dopamine Uptake Inhibitors - pharmacology Ethanol - administration & dosage Ethanol - pharmacology Extinction Laboratory animals Male Narcotics Neurokinin-1 Receptor Antagonists - pharmacology Original Piperidines - pharmacology Rats Rats, Long-Evans Rats, Wistar Receptors, Neurokinin-1 - metabolism Recurrence Saccharin - administration & dosage Species Specificity Stress, Psychological - chemically induced Stress, Psychological - complications Stress, Psychological - metabolism Yohimbine - pharmacology
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