Role of Dynamin-Related Protein 1 (Drp1)-Mediated Mitochondrial Fission in Oxygen Sensing and Constriction of the Ductus Arteriosus

RATIONALE:Closure of the ductus arteriosus (DA) is essential for the transition from fetal to neonatal patterns of circulation. Initial PO2-dependent vasoconstriction causes functional DA closure within minutes. Within days a fibrogenic, proliferative mechanism causes anatomic closure. Though modula...

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Veröffentlicht in:	Circulation research 2013-03, Vol.112 (5), p.802-815
Hauptverfasser:	Hong, Zhigang, Kutty, Shelby, Toth, Peter T, Marsboom, Glenn, Hammel, James M, Chamberlain, Carolyn, Ryan, John J, Zhang, Hannah J, Sharp, Willard W, Morrow, Erik, Trivedi, Kalyani, Weir, E Kenneth, Archer, Stephen L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Calcium - metabolism Cell Proliferation Cells, Cultured Ductus Arteriosus - cytology Ductus Arteriosus - physiology Female GTP Phosphohydrolases - physiology Humans Hydrogen Peroxide - metabolism Infant, Newborn Male Microtubule-Associated Proteins - physiology Mitochondria - metabolism Mitochondrial Dynamics - physiology Mitochondrial Proteins - physiology Models, Animal Muscle, Smooth, Vascular - cytology Muscle, Smooth, Vascular - physiology Oxygen - physiology Oxygen Consumption - physiology Rabbits rho-Associated Kinases - metabolism Tissue Culture Techniques Vasoconstriction - physiology
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