A rehabilitation program for lung cancer patients during postthoracotomy chemotherapy
The objective of this pilot study was to describe the effects of a 16-week home-based rehabilitative exercise program on cancer-related fatigue (CRF), other symptoms, functional status, and quality of life (QOL) for patients with non-small cell lung cancer (NSCLC) after thoracotomy starting within d...
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| Veröffentlicht in: | OncoTargets and therapy 2014-01, Vol.7, p.415-423 |
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| creator | Hoffman, Amy J Brintnall, Ruth Ann von Eye, Alexander Jones, Lee W Alderink, Gordon Patzelt, Lawrence H Brown, Jean K |
| description | The objective of this pilot study was to describe the effects of a 16-week home-based rehabilitative exercise program on cancer-related fatigue (CRF), other symptoms, functional status, and quality of life (QOL) for patients with non-small cell lung cancer (NSCLC) after thoracotomy starting within days after hospital discharge and continuing through the initiation and completion of chemotherapy.
Five patients with NSCLC completed the Brief Fatigue Inventory (measuring CRF severity) and the MD Anderson Symptom Inventory (measuring symptom severity) before and after thoractomy, and at the end of each week of the 16-week exercise program. Additionally, the Medical Outcomes Study Short Form-36 (measuring physical and mental functional status) and the Quality of Life Index (measuring QOL) were completed before and after thoracotomy, after weeks 3, 6, 12, and 16 (the end of the exercise program). Further, the 6-minute walk test (measuring functional capacity) was administered before thoracotomy, prior to the initiation of chemotherapy and/or radiation therapy, and at the end of the 16-week exercise program, after completion of chemotherapy.
Participants had a mean age of 63 years and a mean of five comorbid conditions; the exercise program was initiated within 4 days after hospital discharge. Participants' CRF severity scores were reduced to mild levels, while the mean number of symptoms decreased from 9 postthoracotomy to 6 after the exercise program, with mean levels of severity and interference decreasing to below prethoracotomy levels. Likewise, participants' functional status and QOL after completing the exercise program improved to near or above prethoracotomy levels.
The home-based, light-intensity exercise program for NSCLC patients receiving and completing adjuvant chemotherapy postthoracotomy showed promising trends in improving CRF severity, other symptom severity, functional status, and QOL. Further testing via a two-arm randomized controlled trial is being conducted. |
| doi_str_mv | 10.2147/OTT.S57262 |
| format | Article |
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Five patients with NSCLC completed the Brief Fatigue Inventory (measuring CRF severity) and the MD Anderson Symptom Inventory (measuring symptom severity) before and after thoractomy, and at the end of each week of the 16-week exercise program. Additionally, the Medical Outcomes Study Short Form-36 (measuring physical and mental functional status) and the Quality of Life Index (measuring QOL) were completed before and after thoracotomy, after weeks 3, 6, 12, and 16 (the end of the exercise program). Further, the 6-minute walk test (measuring functional capacity) was administered before thoracotomy, prior to the initiation of chemotherapy and/or radiation therapy, and at the end of the 16-week exercise program, after completion of chemotherapy.
Participants had a mean age of 63 years and a mean of five comorbid conditions; the exercise program was initiated within 4 days after hospital discharge. Participants' CRF severity scores were reduced to mild levels, while the mean number of symptoms decreased from 9 postthoracotomy to 6 after the exercise program, with mean levels of severity and interference decreasing to below prethoracotomy levels. Likewise, participants' functional status and QOL after completing the exercise program improved to near or above prethoracotomy levels.
The home-based, light-intensity exercise program for NSCLC patients receiving and completing adjuvant chemotherapy postthoracotomy showed promising trends in improving CRF severity, other symptom severity, functional status, and QOL. Further testing via a two-arm randomized controlled trial is being conducted.</description><identifier>ISSN: 1178-6930</identifier><identifier>EISSN: 1178-6930</identifier><identifier>DOI: 10.2147/OTT.S57262</identifier><identifier>PMID: 24648745</identifier><language>eng</language><publisher>New Zealand: Dove Medical Press Limited</publisher><subject>Analysis ; Cancer ; cancer-related fatigue ; Care and treatment ; Chemotherapy ; Comorbidity ; Diagnosis ; exercise ; functional status ; Health aspects ; Lung cancer ; Original Research ; Quality of life ; symptoms</subject><ispartof>OncoTargets and therapy, 2014-01, Vol.7, p.415-423</ispartof><rights>COPYRIGHT 2014 Dove Medical Press Limited</rights><rights>2014 Hoffman et al. This work is published by Dove Medical Press Ltd, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c517t-d9bba433b5067521cf4e8e32e26172e82c6468a040de141ea153a75436a758be3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3956688/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3956688/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,3848,27903,27904,53770,53772</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24648745$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hoffman, Amy J</creatorcontrib><creatorcontrib>Brintnall, Ruth Ann</creatorcontrib><creatorcontrib>von Eye, Alexander</creatorcontrib><creatorcontrib>Jones, Lee W</creatorcontrib><creatorcontrib>Alderink, Gordon</creatorcontrib><creatorcontrib>Patzelt, Lawrence H</creatorcontrib><creatorcontrib>Brown, Jean K</creatorcontrib><title>A rehabilitation program for lung cancer patients during postthoracotomy chemotherapy</title><title>OncoTargets and therapy</title><addtitle>Onco Targets Ther</addtitle><description>The objective of this pilot study was to describe the effects of a 16-week home-based rehabilitative exercise program on cancer-related fatigue (CRF), other symptoms, functional status, and quality of life (QOL) for patients with non-small cell lung cancer (NSCLC) after thoracotomy starting within days after hospital discharge and continuing through the initiation and completion of chemotherapy.
Five patients with NSCLC completed the Brief Fatigue Inventory (measuring CRF severity) and the MD Anderson Symptom Inventory (measuring symptom severity) before and after thoractomy, and at the end of each week of the 16-week exercise program. Additionally, the Medical Outcomes Study Short Form-36 (measuring physical and mental functional status) and the Quality of Life Index (measuring QOL) were completed before and after thoracotomy, after weeks 3, 6, 12, and 16 (the end of the exercise program). Further, the 6-minute walk test (measuring functional capacity) was administered before thoracotomy, prior to the initiation of chemotherapy and/or radiation therapy, and at the end of the 16-week exercise program, after completion of chemotherapy.
Participants had a mean age of 63 years and a mean of five comorbid conditions; the exercise program was initiated within 4 days after hospital discharge. Participants' CRF severity scores were reduced to mild levels, while the mean number of symptoms decreased from 9 postthoracotomy to 6 after the exercise program, with mean levels of severity and interference decreasing to below prethoracotomy levels. Likewise, participants' functional status and QOL after completing the exercise program improved to near or above prethoracotomy levels.
The home-based, light-intensity exercise program for NSCLC patients receiving and completing adjuvant chemotherapy postthoracotomy showed promising trends in improving CRF severity, other symptom severity, functional status, and QOL. Further testing via a two-arm randomized controlled trial is being conducted.</description><subject>Analysis</subject><subject>Cancer</subject><subject>cancer-related fatigue</subject><subject>Care and treatment</subject><subject>Chemotherapy</subject><subject>Comorbidity</subject><subject>Diagnosis</subject><subject>exercise</subject><subject>functional status</subject><subject>Health aspects</subject><subject>Lung cancer</subject><subject>Original Research</subject><subject>Quality of life</subject><subject>symptoms</subject><issn>1178-6930</issn><issn>1178-6930</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><recordid>eNptkt1q3DAQhU1padK0N32AYiiUUtiN_mXfBJbQNoVALrK5FrI8XqvIlivJgX37anGa7kIQSGLmO6ORdIriI0Zrgpm8vNtu1_dcEkFeFecYy2olaopeH-3Pincx_kZIiIqwt8UZYYJVkvHz4mFTBuh1Y51NOlk_llPwu6CHsvOhdPO4K40eDYRyymkYUyzbOdgcnnxMqfdBG5_8sC9ND4NPPQQ97d8XbzrtInx4Wi-Khx_ft9c3q9u7n7-uN7crw7FMq7ZuGs0obTgSkhNsOgYVUAJEYEmgIkYwUWnEUAuYYdCYUy05oyLPVQP0orha6k5zM0Brcn9BOzUFO-iwV15bdZoZba92_lHRmue3qHIBtBRo_SNMAWI8Ef-PGj8oLBDnWfL16czg_8wQkxpsNOCcHsHPUWGOaoYpZTKjnxd0px0oO3Y-N2EOuNowjAWmkteZWr9A5dHCYI0fobM5fiL4ciToQbvUR-_mw_fFU_DbAprgYwzQPV8OI3WwjsrWUYt1Mvzp-C2f0X9eoX8BSeG_nA</recordid><startdate>20140101</startdate><enddate>20140101</enddate><creator>Hoffman, Amy J</creator><creator>Brintnall, Ruth Ann</creator><creator>von Eye, Alexander</creator><creator>Jones, Lee W</creator><creator>Alderink, Gordon</creator><creator>Patzelt, Lawrence H</creator><creator>Brown, Jean K</creator><general>Dove Medical Press Limited</general><general>Dove Press</general><general>Dove Medical Press</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20140101</creationdate><title>A rehabilitation program for lung cancer patients during postthoracotomy chemotherapy</title><author>Hoffman, Amy J ; Brintnall, Ruth Ann ; von Eye, Alexander ; Jones, Lee W ; Alderink, Gordon ; Patzelt, Lawrence H ; Brown, Jean K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c517t-d9bba433b5067521cf4e8e32e26172e82c6468a040de141ea153a75436a758be3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Analysis</topic><topic>Cancer</topic><topic>cancer-related fatigue</topic><topic>Care and treatment</topic><topic>Chemotherapy</topic><topic>Comorbidity</topic><topic>Diagnosis</topic><topic>exercise</topic><topic>functional status</topic><topic>Health aspects</topic><topic>Lung cancer</topic><topic>Original Research</topic><topic>Quality of life</topic><topic>symptoms</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hoffman, Amy J</creatorcontrib><creatorcontrib>Brintnall, Ruth Ann</creatorcontrib><creatorcontrib>von Eye, Alexander</creatorcontrib><creatorcontrib>Jones, Lee W</creatorcontrib><creatorcontrib>Alderink, Gordon</creatorcontrib><creatorcontrib>Patzelt, Lawrence H</creatorcontrib><creatorcontrib>Brown, Jean K</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>OncoTargets and therapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hoffman, Amy J</au><au>Brintnall, Ruth Ann</au><au>von Eye, Alexander</au><au>Jones, Lee W</au><au>Alderink, Gordon</au><au>Patzelt, Lawrence H</au><au>Brown, Jean K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A rehabilitation program for lung cancer patients during postthoracotomy chemotherapy</atitle><jtitle>OncoTargets and therapy</jtitle><addtitle>Onco Targets Ther</addtitle><date>2014-01-01</date><risdate>2014</risdate><volume>7</volume><spage>415</spage><epage>423</epage><pages>415-423</pages><issn>1178-6930</issn><eissn>1178-6930</eissn><abstract>The objective of this pilot study was to describe the effects of a 16-week home-based rehabilitative exercise program on cancer-related fatigue (CRF), other symptoms, functional status, and quality of life (QOL) for patients with non-small cell lung cancer (NSCLC) after thoracotomy starting within days after hospital discharge and continuing through the initiation and completion of chemotherapy.
Five patients with NSCLC completed the Brief Fatigue Inventory (measuring CRF severity) and the MD Anderson Symptom Inventory (measuring symptom severity) before and after thoractomy, and at the end of each week of the 16-week exercise program. Additionally, the Medical Outcomes Study Short Form-36 (measuring physical and mental functional status) and the Quality of Life Index (measuring QOL) were completed before and after thoracotomy, after weeks 3, 6, 12, and 16 (the end of the exercise program). Further, the 6-minute walk test (measuring functional capacity) was administered before thoracotomy, prior to the initiation of chemotherapy and/or radiation therapy, and at the end of the 16-week exercise program, after completion of chemotherapy.
Participants had a mean age of 63 years and a mean of five comorbid conditions; the exercise program was initiated within 4 days after hospital discharge. Participants' CRF severity scores were reduced to mild levels, while the mean number of symptoms decreased from 9 postthoracotomy to 6 after the exercise program, with mean levels of severity and interference decreasing to below prethoracotomy levels. Likewise, participants' functional status and QOL after completing the exercise program improved to near or above prethoracotomy levels.
The home-based, light-intensity exercise program for NSCLC patients receiving and completing adjuvant chemotherapy postthoracotomy showed promising trends in improving CRF severity, other symptom severity, functional status, and QOL. Further testing via a two-arm randomized controlled trial is being conducted.</abstract><cop>New Zealand</cop><pub>Dove Medical Press Limited</pub><pmid>24648745</pmid><doi>10.2147/OTT.S57262</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| source | Taylor & Francis Open Access; DOVE Medical Press Journals; PubMed Central Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Analysis Cancer cancer-related fatigue Care and treatment Chemotherapy Comorbidity Diagnosis exercise functional status Health aspects Lung cancer Original Research Quality of life symptoms |
| title | A rehabilitation program for lung cancer patients during postthoracotomy chemotherapy |
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