Nuclear Nox4-Derived Reactive Oxygen Species in Myelodysplastic Syndromes

A role for intracellular ROS production has been recently implicated in the pathogenesis and progression of a wide variety of neoplasias. ROS sources, such as NAD(P)H oxidase (Nox) complexes, are frequently activated in AML (acute myeloid leukemia) blasts and strongly contribute to their proliferati...

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Veröffentlicht in:	BioMed research international 2014-01, Vol.2014 (2014), p.1-11
Hauptverfasser:	Guida, Marianna, Maraldi, Tullia, Beretti, Francesca, Follo, Matilde Y., Manzoli, Lucia, De Pol, Anto
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Apoptosis - drug effects Bone marrow Care and treatment Cell culture Cell Differentiation - drug effects Cell Line, Tumor Cell Nucleus - enzymology Cell Nucleus - metabolism Cell Proliferation - drug effects Colleges & universities Complications and side effects Deoxyribonucleic acid Disease DNA DNA Damage - drug effects Gene expression Genomic Instability Health aspects Humans Kinases Leukemia, Myeloid, Acute - metabolism Leukemia, Myeloid, Acute - pathology Mutation Myelodysplastic syndromes Myelodysplastic Syndromes - enzymology Myelodysplastic Syndromes - metabolism Myelodysplastic Syndromes - pathology NADPH Oxidase 4 NADPH Oxidases - metabolism Oxidation-Reduction Patients Proteins Reactive oxygen species Reactive Oxygen Species - metabolism Reactive Oxygen Species - toxicity
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