Lactoferrin gene knockdown leads to similar effects to iron chelation in human adipocytes

In human and mice adipose tissue, lactoferrin (LTF) has been found to be associated with increased adipogenesis and decreased inflammatory markers. Here, we aimed to investigate the effects of LTF knockdown (KD) in human adipocyte differentiation. In addition, the effects of exogenous LTF administra...

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Veröffentlicht in:	Journal of cellular and molecular medicine 2014-03, Vol.18 (3), p.391-395
Hauptverfasser:	Moreno‐Navarrete, José María, Ortega, Francisco, Moreno, Maria, Serrano, Marta, Ricart, Wifredo, Fernández‐Real, José Manuel
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipocytes Adipocytes - metabolism Adipogenesis Adipogenesis - drug effects Adipose tissue Animal tissues Biomarkers - metabolism Biosynthesis Chelation Deferoxamine Deferoxamine - pharmacology Gene expression Gene Knockdown Techniques Humans Inflammation Inflammation - pathology Insulin Insulin resistance Iron Iron - metabolism Iron Chelating Agents - pharmacology Lactoferrin Lactoferrin - genetics Lactoferrin - pharmacology Lipids Metabolism Obesity Penicillin Proteins Short Communication Therapeutic applications
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