Bone cell-independent benefits of raloxifene on the skeleton: A novel mechanism for improving bone material properties

Abstract Raloxifene is an FDA approved agent used to treat bone loss and decrease fracture risk. In clinical trials and animal studies, raloxifene reduces fracture risk and improves bone mechanical properties, but the mechanisms of action remain unclear because these benefits occur largely independe...

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Veröffentlicht in:	Bone (New York, N.Y.) N.Y.), 2014-04, Vol.61, p.191-200
Hauptverfasser:	Gallant, Maxime A, Brown, Drew M, Hammond, Max, Wallace, Joseph M, Du, Jiang, Deymier-Black, Alix C, Almer, Jonathan D, Stock, Stuart R, Allen, Matthew R, Burr, David B
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Biomechanical Phenomena Bone and Bones - drug effects Bone Density Conservation Agents - pharmacology Dogs Extracellular Matrix - drug effects Fundamental and applied biological sciences. Psychology Humans Mechanical testing Orthopedics Raloxifene Raloxifene Hydrochloride - pharmacology Skeleton Toughness Vertebrates: anatomy and physiology, studies on body, several organs or systems Water
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