The affinity‐selection of a minibody polypeptide inhibitor of human interleukin‐6

A major challenge in basic and applied biological research is the engineering of small proteins with pre‐determined structures and novel functions. In a limited number of cases, this has been achieved by de novo design. An alternative combinatorial approach is based on the construction of large libr...

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Veröffentlicht in:	The EMBO journal 1994-11, Vol.13 (22), p.5303-5309
Hauptverfasser:	Martin, F., Toniatti, C., Salvati, A.L., Venturini, S., Ciliberto, G., Cortese, R., Sollazzo, M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Base Sequence Binding Sites Chromatography, Affinity Codon - genetics Humans Immunoglobulin Heavy Chains - chemistry Immunoglobulin Variable Region - chemistry Interleukin-6 - antagonists & inhibitors Models, Molecular Molecular Sequence Data Peptide Fragments - chemical synthesis Peptide Fragments - chemistry Peptide Fragments - metabolism Peptide Fragments - pharmacology Polymerase Chain Reaction Protein Binding Protein Engineering Protein Structure, Secondary Random Allocation Signal Transduction
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