Sexually dimorphic gastrin releasing peptide system in the spinal cord controls male reproductive functions

Neurons in the upper lumbar spinal cord project axons containing gastrin-releasing peptide (GRP) to innervate lower lumbar regions controlling erection and ejaculation. This system is vestigial in female rats and in males with genetic dysfunction of androgen receptors, but in male rats, pharmacologi...

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Veröffentlicht in:	Nature neuroscience 2008-06, Vol.11 (6), p.634-636
Hauptverfasser:	Sakamoto, Hirotaka, Matsuda, Ken-Ichi, Zuloaga, Damian G, Hongu, Hisayuki, Wada, Etsuko, Wada, Keiji, Jordan, Cynthia L, Breedlove, S Marc, Kawata, Mitsuhiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Androgen-Insensitivity Syndrome - genetics Androgens Animal Genetics and Genomics Animals Behavior, Animal Behavioral Sciences Biological Techniques Biomedical and Life Sciences Biomedicine Bombesin - analogs & derivatives Bombesin - pharmacology brief-communication Castration - methods Cholera Toxin - metabolism Dose-Response Relationship, Drug Ejaculation - drug effects Ejaculation - physiology Female Females Gastrin-Releasing Peptide - pharmacology Gastrin-Releasing Peptide - physiology Horseradish Peroxidase - metabolism Human reproduction Male Males Neurobiology Neurons Neurosciences Nitric Oxide Synthase Type I - metabolism Penile Erection - drug effects Penile Erection - physiology Penis Peptide Fragments - pharmacology Peptides Physiological aspects Protein Binding - drug effects Rats Rats, Long-Evans Rats, Mutant Strains Rats, Sprague-Dawley Reaction Time - drug effects Reaction Time - physiology Receptors, Androgen - genetics Sex Characteristics Spinal cord Spinal Cord - metabolism Testosterone - metabolism
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