Regulation of mitosis and taxane response by Daxx and Rassf1

Current theories suggest that mitotic checkpoint proteins are essential for proper cellular response to taxanes, a widely used family of chemotherapeutic compounds. We recently showed that absence or depletion of protein Daxx increases cellular taxol (paclitaxel) resistance—a common trait of patient...

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Veröffentlicht in:	Oncogene 2012-01, Vol.31 (1), p.13-26
Hauptverfasser:	Giovinazzi, S, Lindsay, C R, Morozov, V M, Escobar-Cabrera, E, Summers, M K, Han, H S, McIntosh, L P, Ishov, A M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - physiology Anaphase Animal models Animals Antimitotic agents Antineoplastic agents Antineoplastic Agents, Phytogenic - pharmacology Apoptosis Binding sites Breast cancer Breast Neoplasms - drug therapy Cell Biology Cell Cycle Cell Line, Tumor Chemotherapy Cyclin B Cyclin B1 - analysis Data processing Daxx protein Drug Resistance, Neoplasm Drug therapy Female Genes Genetic aspects Health aspects Human Genetics Humans Internal Medicine Malignancy Medicine Medicine & Public Health Mice Mitosis Mitosis - drug effects Nuclear Proteins - physiology Oncology original-article Paclitaxel Paclitaxel - pharmacology Physiological aspects Proteins Stress taxanes Tumor Suppressor Proteins - chemistry Tumor Suppressor Proteins - physiology Tumors Ubiquitin-protein ligase Xenografts
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