Mice devoid of interferon regulatory factor 1 (IRF‐1) show normal expression of type I interferon genes

The transcription factor interferon regulatory factor 1 (IRF‐1) binds tightly to the interferon (IFN)‐beta promoter and has been implicated in the induction of type I IFNs. We generated mice devoid of functional IRF‐1 by targeted gene disruption. As reported by others, IRF‐1‐deficient mice showed a...

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Veröffentlicht in:	The EMBO journal 1994-10, Vol.13 (20), p.4798-4806
Hauptverfasser:	Reis, L.F., Ruffner, H., Stark, G., Aguet, M., Weissmann, C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line DNA-Binding Proteins - physiology Female Gene Expression Regulation - physiology Interferon Regulatory Factor-1 Interferon Type I - genetics Male Mice Mice, Inbred C57BL Mice, Inbred ICR Molecular Sequence Data Phosphoproteins - physiology Transcription Factors - physiology
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