Extracellular HMGB1 promotes differentiation of nurse-like cells in chronic lymphocytic leukemia

Chronic lymphocytic leukemia (CLL) is a disease of an accumulation of mature B cells that are highly dependent on the microenvironment for maintenance and expansion. However, little is known regarding the mechanisms whereby CLL cells create their favorable microenvironment for survival. High-mobilit...

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Veröffentlicht in:	Blood 2014-03, Vol.123 (11), p.1709-1719
Hauptverfasser:	Jia, Li, Clear, Andrew, Liu, Feng-Ting, Matthews, Janet, Uddin, Nadiha, McCarthy, Aine, Hoxha, Elena, Durance, Catherine, Iqbal, Sameena, Gribben, John G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Blotting, Western Case-Control Studies Cell Differentiation Cell Proliferation Coculture Techniques Culture Media, Conditioned Enzyme-Linked Immunosorbent Assay Flow Cytometry Fluorescent Antibody Technique Follow-Up Studies HMGB1 Protein - metabolism Humans Immunoprecipitation Leukemia, Lymphocytic, Chronic, B-Cell - metabolism Leukemia, Lymphocytic, Chronic, B-Cell - mortality Leukemia, Lymphocytic, Chronic, B-Cell - pathology Lymph Nodes - metabolism Lymph Nodes - pathology Lymphoid Neoplasia Neoplasm Recurrence, Local - metabolism Neoplasm Recurrence, Local - mortality Neoplasm Recurrence, Local - pathology Plasma Cells - metabolism Plasma Cells - pathology Prognosis Receptor for Advanced Glycation End Products - metabolism Signal Transduction Survival Rate Tissue Array Analysis Toll-Like Receptor 9 - metabolism Tumor Cells, Cultured Tumor Microenvironment
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