Quinacrine Inhibits Cell Growth and Induces Apoptosis in Human Gastric Cancer Cell Line SGC-7901

Abstract Background Quinacrine (QC), an antimalarial drug, has been shown to possess anticancer effect both in vitro (cancer cell lines) and in vivo (mouse models). In the cancer cells, QC can simultaneously suppress nuclear factor-κB and activate p53 signaling, which results in the induction of the...

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Veröffentlicht in:	Current therapeutic research 2012-02, Vol.73 (1), p.52-64
Hauptverfasser:	Wu, Xiaoyang, PhD, Wang, Yunliang, PhD, Wang, Hongwei, PhD, Wang, Qiang, PhD, Wang, Lin, MS, Miao, Jingcheng, MS, Cui, Fengmei, PhD, Wang, Jinzhi, PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	apoptosis Bax Bcl-2 Biological and medical sciences Gastroenterology. Liver. Pancreas. Abdomen Internal Medicine Medical Education Medical sciences Original Research p53 Pharmacology. Drug treatments quinacrine SGC-7901 cells Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tumors
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